聚乳酸-羟基乙酸药物控释微型装置的制备  

Preparation of Controlled-release PLGA Honeycomb-structures

作　　者：钱良山[1] 王小鹏[1] 陈天宁[1] 

机构地区：[1]西安交通大学机械工程学院,陕西西安710049

出　　处：《中国医药工业杂志》2006年第5期322-324,共3页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金资助项目(50375116);国家"863"高技术研究发展项目(2003AA404170)

摘　　要：利用不同规格的聚乳酸-羟基乙酸(PLGA)设计并制备了一种多腔体可降解的植入式药物控释微型装置,并考察了亲水性药物对乙酰氨基酚和氯苯那敏在不同规格PLGA微型装置中的释药情况。结果表明,单纯依靠扩散作用不能实现长期恒速释药,而带微孔的该类微型装置的累积释药量线性度较好,有可能适用于植入式长期控释给药。An implantable controlled-release micro-device with multi-chambers using PLGA of different molar ratio as biodegradable matirx was designed and fabricated. The in vitro release of the micro-devices encapsulated with paracetamol and chlorpheniramine was investigated, respectively. The results showed that the long-term and controlled-release effect could not be achieved only relied on diffusion and corrosion, but the devices with pores on PLGA film could realize preferable linear release, which indicated it was a potential dosage form for implantable long-term controlled drug release system.

关 键 词：PLGA 药物控释 生物降解 

分 类 号：R944.9[医药卫生—药剂学]