239例病毒性肝炎病人血小板参数和凝血功能变化的临床意义  

Changes of Platelet Parameter and Coagulative Function in 239 Patients with Hepatitis

作　　者：李玉芳[1] 刘娅[1] 李占军[2] 

机构地区：[1]宁夏医学院附属医院感染疾病科,银川750004 [2]宁夏医学院附属医院检验科,银川750004

出　　处：《宁夏医学院学报》2006年第2期125-126,132,共3页Journal of Ningxia Medical College

摘　　要：目的观察肝硬化和重度肝硬化在未出血前血小板参数、凝血功能的变化。方法收集各型病毒性肝炎患者239例(急性肝炎组、慢性肝炎组、重型肝炎组和肝硬化组),并选择42例健康人群作对照,检测血小板计数(PLT)、平均血小板体积(MPC)、血小板压积(PCT)和血小板分布宽度(PDW)。检测凝血酶原时间(PT)、部分凝血酶时间(APTT)、凝血酶原时间活动度(PTA)、纤维蛋白原(FIB),比较各组上述指标的变化。结果 PT、 APTT、FIB三项参数,急性肝炎组、慢性肝炎组、重型肝炎组和肝硬化组四组与对照组比较,以及组间比较均 P<0．05,有统计学意义,其中重型肝炎组FIB下降水平最突出;PFA显示急性肝炎组、慢性肝炎组、重型肝炎组和肝硬化组四组组间比较差异有统计学意义(P<0．01);各型病毒性肝炎患者血小板参数均有不同程度的下降(P<0．05);肝硬化和重型肝炎在未出血之前,PLT、PCT二指标已有明显下降(P<0．001),在肝硬化出血组,PLT、PCT与PTA同步下降,呈正相关(r分别为0.46、0．37)。结论各型病毒性肝炎患者血小板参数、凝血功能都发生不同的变化,并且肝硬化和重型肝炎有严重出血者出血前就存在血小板数量和质量上的异常。Objective To observe the effects of resecting levator palpebrae superioris muscle on treating moderate and severe congenital ptosis. Methods Fourty and one eyes in 29 cases with moderate or severe congenital ptosis were treated by shortening palpebrae superioris muscle via percutem - conjunctiva palpebrae. The results of postoperation were following up. Results The postoperative effects in 41 eyes were followed up for 2 - 18 months, except for undercorrection in 2 cases, all others had a good outcome. The radian of lidmargin and double blephara shaped well. Only some presented a slight dysraphism in the early stage of postoperation, and no exposure keratitis and other severe complications occurred. Conclusion Levator palpebrae superioris muscle shortening can be used to treat moderate or severe congenital ptosis and to correct the deformity and achieve cosmetic effect simultaneously.

关 键 词：病毒性肝炎 肝硬化 血小板 凝血功能 

分 类 号：R512.6[医药卫生—内科学]