L-缬氨酸甲酯修饰石墨电极不对称还原苯乙酮  

Asymmetric Reduction of Acetophenone Using L-Valine Methyl Ester Modified Graphite Electrode

作　　者：陈刚[1] 陆嘉星[1] 徐承天[1] 陈良[1] 张五昌[1] 

机构地区：[1]华东师范大学化学系

出　　处：《应用化学》1996年第3期87-89,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助课题

摘　　要：电化学不对称还原与普通化学方法相比有反应条件温和、易于控制、手性试剂用量小、产物纯、易于分离等优点,受到人们重视.1975年 Miller 等将 L-苯丙氨酸甲酯通过酰胺键修饰到石墨电极表面,用于还原4-乙酰吡啶和苯甲酰甲酸乙酯,均获旋光性产物,而We have prepared covalently modified graphite electrodes(CelValM)that bind L-valine methyl ester to their surface via amide bonds,thereby providing a stable,chiral in- terfacial region for the reduction of acetophenone.The optical yield(o.y.)and chemical yield (c.y.)of S(-)-1-phenylethanol were measured as a function of CelValM cathode potential, current density,amount of electricity passed,substrate concentration,pH,and the number of repeated use of electrodes.The highest o.y.was 15.8%.The characteristics and kinetic parameters of electrode processes were determined by potentiodynamic method and rotating disk electrode.A possible mechanism of the asymmetric electroreduction of acetophenone was forwarded.

关 键 词：L-缬氨酸甲酯 修饰电极 不对称还原 苯乙酮 

分 类 号：O625.42[理学—有机化学] O646.54[理学—化学]