代谢综合征患者血清游离脂肪酸成分特征的研究  

Study on Serum Free Fatty Acid Composition in Patients with the Metabolic Syndrome

作　　者：李嘉强[1] 戴颖秀 刘玉敏[2] 郑基 刘文斌 

机构地区：[1]上海市杨浦区疾病预防控制中心,上海200090 [2]上海交通大学分析测试中心,上海200030 [3]上海市杨浦区平凉社区卫生服务中心,上海200082 [4]上海市杨浦区五角场社区卫生服务中心,上海200433

出　　处：《中国慢性病预防与控制》2006年第2期85-88,共4页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：上海市杨浦区卫生局科研基金资助(2002AA001-005)

摘　　要：目的研究代谢综合征M(S)及高危患者血清游离脂肪酸(FFA)成分特征及与其他糖脂代谢参数间关系。方法用气相色谱-质谱(GCM-S)联用法测定159名MS及MS高危患者与43例正常对照者血清游离脂肪酸成分水平。结果MS患者不饱和脂肪酸(C18:2、C18:1、C20:4、C22:6、C20:3)高于正常对照组C,18:2、C20:3有统计学意义P(<0.01);不饱和脂肪酸/总脂肪酸(UFAT/FA)、多不饱和脂肪酸/总脂肪酸(PUFAT/FA)、多不饱和脂肪酸/饱和脂肪酸(PUFAS/FA)高于正常对照组(P<0.01);SFA(C16:0、C18:0)和SFAT/FA低于正常对照组P(<0.01)。MS组与MS高危组相比F,FA各指标无统计学意义(P>0.05)。研究对象血糖与UFAT/FA、PUFAT/FA、PUFAS/FA呈显著正相关(r=0.229,0.204,0.230,P<0.01),血糖与SFA/TFA呈显著负相关(r=-0.229,P<0.01)。结论MS及MS高危患者中存在游离脂肪酸代谢紊乱。n6系多不饱和脂肪酸升高,可能在MS发病中起重要作用。Objective To explore the difference of serum free fatty acid （FFA） composition between the patients with the metabolic syndrome （MS） and the patients with high risk for MS （HRMS）, and the relationship of FFA composition with their serum glucose. Methods The serum fatty acid profile was measured with the gas chromatography and mass spectrometer （GC/MS）in 159 patients with MS or HRMS and 43 control subjects. Results The contents of unsaturated fatty acid （UFA, C18：2 and C20：3）, the ratios of UFA/TFA （total fatty acid）, PUFA（polyunsaturated fatty acid）/TFA and PUFA/SFA（saturated fatty acid） were significantly increased in patients with MS than those in the normal controls （P〈0.01）. But the contents of saturated fatty acid （SFA, C16：0 and C18：0） and ratio of SFA/TFA were remarkably decreased in MS patients than those in the normal controls （P〈0.01）. There was no significant difference of above mentioned FFA composition between patients with MS and HRMS （P〉0.05）. FBG had remarkably positive correlation with UFA/TFA, PUFA/TFA and PUFA/SFA （r=0.229,0.204,0.230, P〈0.01, respectively）and a negative correlation with SFA/TFA （r=-0.229, P〈0.01 ）in all subjects. Conclusion This study suggests that there was the FFA metabolic abnormality in patients with the metabolic syndrome and with high risk for MS. Increased levels of n-6 PUFA may play an important role in the pathogenesis of the metabolic syndrome.

关 键 词：代谢综合征 游离脂肪酸谱 气相色谱/质谱联用技术 

分 类 号：R587.1[医药卫生—内分泌]