富勒醇清除·OH自由基的ESR研究  

An ESR Study on OH-radical Scavenging Activity of Water-soluble Fullerenols

作　　者：祝严师[1] 孙大勇[1] 刘桂珍[1] 刘子阳[1] 詹瑞云[1] 刘淑莹[1] 

机构地区：[1]中国科学院长春应用化学研究所应用谱学开放实验室

出　　处：《高等学校化学学报》1996年第7期1127-1129,共3页Chemical Journal of Chinese Universities

基　　金：中国科学院应用谱学开放实验室和延边敖东药业集团公司资助

摘　　要：富勒醇清除·ＯＨ自由基的ＥＳＲ研究祝严师，孙大勇，刘桂珍，刘子阳，詹瑞云，刘淑莹（中国科学院长春应用化学研究所应用谱学开放实验室，长春，１３００２２）关键词Ｃ_（６０），富勒醇，ＯＨ自由基，自旋捕捉，ＥＳＲ生物体内的许多现象均涉及到自由基反应，现已发?..Water-soluble polyhydroxylated fullerene derivatives(fullerenol) were synthesized,and their scavenging ability for OH-radical was studied by the combination of ESR spectroscopy and spin-trapping technique with phenyl-t-butyl-nitrone. It was found that fullerenols showed an excellent efficiency in eliminating OH free radicals generated by UV photolysis of H2O2.At an applied fullerenol concentration of 0.3mg/mL in the final solution,a radical scavenging efficiency of approximate 95%was achieved, revealing the potential use of these compounds as novel potent free radical scavengers in biological systems.

关 键 词：C_60 富勒醇 OH自由基 自旋捕捉 ESR 

分 类 号：O635.1[理学—高分子化学] O641.13[理学—化学]