急性心肌梗死介入治疗中Percusurge远端保护装置对血浆内皮素-1及白细胞介素-6变化的影响  

Influences of Percusurge distal protection device on the level of endothelium-1(ET-1),interleukin-6(IL-6)in coronary intervention in acute myocardial infarction

作　　者：郭瑄[1] 李成祥[1] 王海昌[1] 贾国良[1] 曹丰[1] 冯旭阳[1] 高延[1] 

机构地区：[1]解放军第四军医大学西京医院心脏内科,陕西西安710032

出　　处：《中国急救医学》2006年第5期326-328,共3页Chinese Journal of Critical Care Medicine

基　　金：第四军医大学西京医院科技创新基金(No.XJCX03M019)

摘　　要：目的探讨Percusurge远端保护装置(DPD)在急性心肌梗死(AMI)介入治疗中对冠状窦血浆内皮素-1(ET-1)、白细胞介素-6(IL-6)的影响及作用机制。方法48例接受急诊PCI治疗的AMI患者,随机分为DPD组(25例)、对照组(23例),经股静脉将6F右冠状动脉造影导管置入冠状静脉窦,于PTCA前、术后即刻、术后2h、术后6h共4个时间点采血,分别检测血浆中ET-1、IL-6水平。结果PCI术前两组ET-1、IL-6含量差异无统计学意义(P>0·05)。DPD组术前及术后3个时间点血浆ET-1含量差异无统计学意义,对照组术后2h、6h血浆ET-1水平明显升高(P<0·05),与DPD组比较差异有统计学意义(P<0·05)。DPD组术后即刻至6h IL-6浓度显著降低(P<0·05),明显低于对照组(P<0·05)。结论Percusurge远端保护装置能有效保护远端血管,避免内皮损伤,降低炎症反应。Objective To investigate influences of Percusurge distal protection device （DPD）on the level of endothelium -1 （ET- 1 ） ,interleukin -6（ IL- 6）in coronary intervention in acute myocardial infarction. Methods 48 acute STEMI patients who received primary coronary intervention were included into this study. Patients were divided into two groups according to whether Percusurge DPD was attempted during emergency PCI. Placing a right coronary artery catheter into the coronary sinus, blood sample was drawn to measure endothelium - 1 （ ET - 1 ）, Interleukin - 6 （ IL - 6）. Results The ET - 1 and IL - 6 level was no significant difference between the two groups after PCI, ET - 1 level was significant lower at 2 hour and 6 hour compared with control, IL -6 level was significant lower from right to 6 hour compared with control. Conclusions DPD could protect the distal vessels effectively and reduce the endothelium injury, and the inflamation.

关 键 词：急性心肌梗死 Percusurge远端保护装置 急诊冠状动脉介入治疗 内皮素-1 白细胞介素-6 

分 类 号：R542.22[医药卫生—心血管疾病]