早期应用阿托伐他汀对急性冠脉综合征患者血清妊娠相关蛋白-A和高敏C-反应蛋白水平的影响  

Effects of atorvastain therapy on serum PPAP-A,hs-CRP levels of patients with acute coronary syndrome in early stage

作　　者：付华[1] 刘亚林[1] 刘宇[1] 

机构地区：[1]河北医科大学附属第四医院心内科,河北石家庄050011

出　　处：《中国急救医学》2006年第5期334-336,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的研究早期应用阿托伐他汀对急性冠脉综合征患者稳定斑块、减少炎症反应的作用。方法采用随机、对照的方法,将88例急性冠脉综合征患者分为他汀治疗组(阿托伐他汀10mg/d,n=45)和常规治疗组(n=43);治疗前后分别测定血清妊娠相关血浆蛋白A(PAPP-A)、高敏C-反应蛋白(hs-CRP)水平。另设健康对照组(n=30)与之对照。结果①治疗前他汀治疗组和常规治疗组的血清PAPP-A和hs-CRP水平均较健康对照组显著增高(P均<0·01),与血脂水平不相关。②他汀治疗组经阿托伐他汀治疗8周后血清PAPP-A及hs-CRP水平均较治疗前明显降低(P<0·01),常规治疗组除血清hs-CRP水平降低外(P<0·05),其他各项指标均无变化。结论早期应用阿托伐他汀治疗可减少急性冠脉综合征患者冠状动脉粥样斑块破裂和炎症反应,具有稳定斑块的作用。Objective To observe the influences of atorvastain on serum pregnancy - associated plasma protein A（ PAPP -A） and high sensitive C -reactive protein （hs - CRP） levels of patients with acute coronary syndrome（ACS） in early stage. Methods Eighty - eight patients with ACS were assigned to atorvastain group （ 10 mg/d of atorvastain for 8 weeks ,n =45 ） or control group （ No lipid -lowering drugs were used, n = 43 ） in a randomized, double -blind ,controlled study. Serum levels of PAPP - A and hs - CRP were, detected before and after treatment. Results①Patients with ACS had higher levels of serum PAPP - A and hs - CRP,compared with those of the healthy controls （P 〈 0. 01, n = 30）, which were not correlated with levels of serum lipids. ② After atorvastaln treatment, the levels of serum PAPP - A and hs - CRP, were significantly decreased （ P 〈 0. 01 ）. Conclusions Atorvastain＇ decreased the breakdown of matrix collagen.and reduced inflammatory reaction in the patients with ACS. It has certain effect on plaque stabilization.

关 键 词：阿托伐他汀 急性冠脉综合征 妊娠相关血浆蛋白A 高敏C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]