康脑液对脑缺血大鼠软脑膜微循环的影响  

Effects of Kangnaoye on Pia Mater Microcirculation in Rats Subjected to Cerebral Ischemia

作　　者：韩敏[1] 邹玉安[2] 薛茜[2] 张静[1] 张玉平[1] 杜舒婷[1] 

机构地区：[1]河北北方学院医学院病理生理教研室,邮政编码张家口075029 [2]河北北方学院第一附属医院

出　　处：《微循环学杂志》2006年第2期21-23,共3页Chinese Journal of Microcirculation

基　　金：河北省中医药管理局资助项目(2004073)

摘　　要：脑血管病是人类三大死亡原因之一，其中，缺血性脑血管病占相当大的比例。脑微循环障碍是缺血性脑血管病的主要发病环节之一，改善脑微循环障碍是治疗缺血性脑血管病的一个重要措施。为此，我们在前人经验的基础上，自制了复方制剂康脑液，观察其对大鼠脑缺血软脑膜微循环障碍的干预作用，为临床开发利用中药提供实验依据。Objective: To study the interference action of self-made Kangnaoye (made for traditional Chinese herbal medicine) on pia mater microcirculation after cerebral ischemia in rats.Method: The revised method described by Bannister was adopted to establish the experimental model of rats common cartoid arteries ischemia. Twenty-two male Wistar rats were randomly assigned to the two groups. The rats in Kangnaoye group were intubated orally with 2 ml Kangnaoye once daily for 18d, the Kangnaoye replaced by the equivalent volume of normal saline(NS) in modle group. The pia mater microcirculation was studied by using a vital microscope with TV recorder before and after making model. Results: (1)The distubance of the pia mater micro-blood flow condition was improved. The micro-blood speed slowed and the red cell aggregated after making madel in Kangnaoye grope was obviously lighter than that of model group (P<0.05-0.01). (2) The effect of diameter of pia mater micro-vessels contracted that was caused by cerebral ischemia was antagonized(P<0.05-0.01). (3) The capillary intersections in Kangnaoye group more than that of model group(P<0.05-0.01).Conclusion: Kangnaoye could markedly improve the pia mater microcirculation and had a neuroprotective effect on cerebral ischemia in rats .

关 键 词：软脑膜微循环 康脑液 缺血大鼠 缺血性脑血管病 脑微循环障碍 大鼠脑缺血 死亡原因 复方制剂 干预作用 开发利 

分 类 号：R331.35[医药卫生—人体生理学] R743.33[医药卫生—基础医学]