加味四逆散防治大鼠酒精性肝病实验研究  

Experimental Study of the Effect of Jiaweisinisan on Alcohol Liver Diseases

作　　者：郭晓萍[1] 程宇甫 袁勤钊[3] 王国华[1] 卢志雁[1] 

机构地区：[1]大同大学医学院,山西大同037008 [2]大同市第五医院,山西大同037000 [3]山西省第三人民医院,山西太原030013

出　　处：《中国中医药信息杂志》2006年第5期33-34,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：大同市科技局资助项目(O3-2-E51)

摘　　要：目的观察加味四逆散对酒精性肝病大鼠的防护作用。方法采用乙醇灌胃法制备酒精性肝病大鼠模型,以小柴胡颗粒作对照,检测肝功能及肝组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、过氧化氢酶(CAT)、脂质过氧化产物丙二醛(MDA)含量,并观察肝组织病理变化。结果加味四逆散可明显减轻肝组织损伤,显著降低MDA含量,使SOD、GSH-PX、CAT含量明显升高。结论加味四逆散具有抗脂质过氧化、保护肝细胞、防治酒精性肝病的作用。Objective To observe the pharmacological effect of Jiaweisinisan （JWSNS） on alcohol liver diseases. Methods Feeding Wistar rats with alcohol induced the alcohol liver diseases model. Then JWSNS was used on the alcohol liver diseases model to observe the histological variation of liver and detect the effect on the liver＇s expression of SOD, GSH-PX, CAT and MDA. At the same time, Xiaochaihu granule group was used as control. Results On the alcohol liver diseases model group processed with JWSNS, obvious decrease of pathological injury with expression of MDA in liver was observed, while a markedly increased expression of SOD, GSH-PX and CAT was detected. Conclusions JWSNS can prevent liver cells from peroxided injury by alcohol.

关 键 词：加味四逆散 酒精性肝病 实验研究 

分 类 号：R285.5[医药卫生—中药学]