TNF-α在银屑病的发病及治疗中的研究进展  

Research advances of TNF-α in the mechanisms and treatment of psoriasis

作　　者：刘骅[1] 金涌[1] 

机构地区：[1]安徽医科大学药学院,安徽合肥230032

出　　处：《安徽医药》2006年第5期321-323,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省教育厅自然科学研究项目:2004kj196安;徽医科大学博士基金课题

摘　　要：近年来的研究显示,肿瘤坏死因子-α(TNF-α)在宿主防御和致炎过程中发挥了重要作用。在银屑病患者的皮损区和循环血液中发现TNF-α的过分表达,提示TNF-α在银屑病中起着至关重要的作用。临床试验已经证明抑制TNF-α活性能有效对抗银屑病。该文主要总结TNF-α与银屑病的关系、抑制TNF-α的生物制剂以及这些制剂的临床和免疫效果。Numerous recent investigations have pointed out a key role of the tumor necrosis factor-α （TNF-α） in host defense and inflammatory processes. TNF-α overexpression has been found in lesional skin and in the circulation of psoriatic patients, and it was suggested that TNF-α is crucial in psoriasis. Several approaches to inhibiting TNF-α activity have been developed. Clinical trials have demonstrated significant antipsoriatic effects. This article reviews the relationship of TNF-α and psoriasis, the biological preparations to inhibit TNF-α activity, and their clinical and immunological effects in psoriasis.

关 键 词：细胞因子 TNF-Α 银屑病 免疫治疗 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]