Synthesis and Characterization of Poly(L-lactide-co-glycolide)  

作　　者：刘丽莉 蔡伟 

机构地区：[1]School of Materials Science and Engineering, Harbin Institute of Technology, P.O. Box 405, Harbin 150001, China

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2005年第B12期217-219,共3页武汉理工大学学报（材料科学英文版）

基　　金：FundedbytheNationalNaturalScienceFoundationofHeilongjiangProvince(No.ZJG0502)

摘　　要：Poly （ l- lactide- co-glycolide ） （ PLGA ） with different compositions was prepared using stannous octaoate as catalyst by bulk ring-opening copolymerization of l-lactide and glycolide. The structure and properties of the PLGA copolymers were cbaracterized by means of attenuated total reflectance-Fourier transform infrared （ATR-FTIR）, ^1H NMR, differential scanning calorimeter （ DSC and X-ray diffraction （XRD） methods, The experimented results indicate that the synthetic conditions and the composition of copolymers have art obvious influence on the structure of PLGA copolymers, The degradation rate of eopolymers increased with the increasing of the glycolide component in the copolymers.Poly （ l- lactide- co-glycolide ） （ PLGA ） with different compositions was prepared using stannous octaoate as catalyst by bulk ring-opening copolymerization of l-lactide and glycolide. The structure and properties of the PLGA copolymers were cbaracterized by means of attenuated total reflectance-Fourier transform infrared （ATR-FTIR）, ^1H NMR, differential scanning calorimeter （ DSC and X-ray diffraction （XRD） methods, The experimented results indicate that the synthetic conditions and the composition of copolymers have art obvious influence on the structure of PLGA copolymers, The degradation rate of eopolymers increased with the increasing of the glycolide component in the copolymers.

关 键 词：Poly （ l- lactide-co-glycolide ） COPOLYMERS degradation biodegradable 

分 类 号：O631.3[理学—高分子化学]