Changes of dipalmitoyl phosphatidyl choline after mechanical ventilation in patients with acute cerebral injury  

作　　者：黄卫东 周道扬 杨云梅 徐哲荣 沈美亚 苏伟 

机构地区：[1]Department of Emergency,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China [2]Cadre's Ward (used to be the Department of Emergency),First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China

出　　处：《Chinese Journal of Traumatology》2006年第3期187-189,共3页中华创伤杂志（英文版）

基　　金：This study was supported by Zhejiang Provincial Program Funds of the Science and Technology Department ( No. 2004C33048)by funds of Science and Technology Department of Hangzhou City (No. 2004C33368).

摘　　要：Objective： To detect the levels of dipalmitoyl phosphatidyl choline （DPPC） in the sputum of the patients with acute cerebral injury without primary pulmonary injury after mechanical ventilation treatment. Methods： DPPC levels in sputum of 35 patients with acute cerebral injury but without pulmonary injury were detected with high performance liquid chromatography at the beginning of ventilation and 16-20 days, 21-40 days, and 41-60 days after ventilation, respectively. Results： There was no significant difference of the DPPC levels between 16-20 days after ventilation （3.36±0.49） and at the beginning of ventilation （3.37 ± 0.58 ） （P〉0.05）. The mean levels of DPPC decreased significantly at 21-40 days （2.87 mg/ml ±0.26 mg/ml, P〈0.05） and 41-60 days （1.93 mg/ml ±0.21 mg/ml, P〈0.01 ） after ventilation compared with that at the beginning of ventilation. At the same period, the peak inspiratory pressure and the mean pressure of airway increased significantly, whereas the static compliance and the partial pressure of oxygen in artery decreased significantly. Among the 25 patients who received ventilation for more than 20 days, 8 （32%） had slightly-decreased partial pressure of oxygen in artery compared with that at the beginning of ventilation. Conclusions： Mechanical ventilation can decrease the DPPC levels, decrease the lung compliance and increase the airway pressure, even impair the oxygenation function in patients with acute cerebral injury. Abnormal DPPC is one of the major causes of ventilator-associated lung injury.

关 键 词：Respiration  artificial Brain injuries 1  2-Dipalmitoylphosphatidylcholine Ventilator-associatedlung injury 

分 类 号：R651.1[医药卫生—外科学]