染料木黄酮抑制小鼠变应性接触性皮炎的实验研究  

Inhibitory effects of genistein on mouse allergic contact dermatitis

作　　者：丛林[1] 曾耀英[2] 蔡小嫦[1] 易敏[1] 施军[1] 

机构地区：[1]暨南大学附属第一医院皮肤科 [2]暨南大学组织移植与免疫教育部重点实验室,广东广州510632

出　　处：《中国病理生理杂志》2006年第5期885-888,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金重点项目(No.30230350);国家自然科学青年基金项目(No.30500466)

摘　　要：目的:探讨染料木黄酮(Gen)对小鼠变应性接触性皮炎(ACD)的抑制作用。方法:建立二硝基氟苯(DNFB)诱发的小鼠ACD模型,观测不同剂量Gen对小鼠耳廓肿胀程度、鼠耳皮肤组织病理变化、体重及胸腺指数、脾指数的影响。结果:各剂量Gen组均能明显抑制DNFB诱发的小鼠耳廓肿胀,抑制炎症细胞浸润,降低胸腺指数,且不影响小鼠体重增长。低剂量Gen组增加脾指数,高剂量Gen组降低脾指数。结论:Gen对DNFB诱发的小鼠ACD有明显抑制作用。AIM： To investigate the inhibitory effects of genistein （Gen） on mouse allergic contact dermatitis （ACD）. METHODS： The animal model of ACD was induced by DNFB. The effects of different doses of Gen on mouse ear swelling, body weight, histopathologieal charges in mouse ear skin, thymus index and spleen index were observed. RESULTS： All groups of Gen inhibited mouse ear swelling induced by DNFB significantly. The infiltration of inflammatory cells and thymus index were also reduced. However, the increase in mouse body weight was not affected, low dose of Gen increased spleen index, high dose of Gen decreased spleen index. CONCLUSION： Genistein has significant inhibitory effects on mouse ACD induced by DNFB.

关 键 词：染料木黄酮 变应性接触性皮炎 实验 

分 类 号：R758.22[医药卫生—皮肤病学与性病学] R965[医药卫生—临床医学]