葛根素对胰岛素抵抗模型大鼠调脂降压作用及其机制研究  

Effect of puerarin on blood pressure and serum lipid in a rat model of insulin resistance

作　　者：吕俊华[1] 张世平[1] 玉从容[1] 

机构地区：[1]暨南大学药学院药理教研室,广东广州510632

出　　处：《中国病理生理杂志》2006年第5期997-1000,共4页Chinese Journal of Pathophysiology

摘　　要：目的:研究葛根素对胰岛素抵抗模型大鼠血脂血压的影响,并探讨其作用机制。方法:采用高脂、高糖和高盐饲料喂养大鼠,饲养8周时,给予葛根素,每天1次,连续4周,并于末次给药后测定各组大鼠空腹血糖、血脂、胰岛素水平及血中丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、肾素(renin)、血管紧张素Ⅱ(AngⅡ)水平和超氧化物歧化酶(SOD)活性。结果:葛根素高、中剂量组具有降低胰岛素抵抗模型大鼠血压、血脂和AngⅡ水平的作用,并提高胰岛素敏感指数;葛根素高剂量组能够显著降低MDA、TNF-α水平,升高SOD活性。结论:葛根素对胰岛素抵抗时的高血脂和高血压具有调脂降压作用,其作用机制可能与其影响肾素-血管紧张素系统活动、氧自由基及TNF-α因子生成等有关。AIM： To observe the effects of puerarin on blood pressure （BP）, serum lipid in a rat model of insulin resistance and the mechanism. METHODS： Adult SD rats were maintained on high - fat - sugar- salt diet for 12 weeks. Puerarin was administered to the rats from 9th week for 4 weeks by intramuscular injection. BP was measured at the end of 0, 8th, 12th week. The levels of serum glucose, serum lipid, fasting serum insulin and the levels of MDA, TNF - α, plasma rennin, angiotensin Ⅱ （ AngⅡ ） and the activity of SOD were measured and the insulin - sensitivity index was also calculated at the end of the experiment. RESULTS： High and middle dosage of puerarin significantly decreased blood pressure, reduced the levels of serum lipid and AngⅡ , and also increased insulin - sensitivity index. The levels of MDA and TNF - α were significantly decreased by high dosage of puerarin. The activity of SOD was increased significantly. CONCLUSIONS： Puerarin possesses the effects of decreasing the blood pressure and serum lipid in a rat model of insulin resistance, which may be concerned with the changes of rennin - angiotensin system, the levels of oxygen - derived free radicals and TNF - α.

关 键 词：葛根素 胰岛素抗药性 血脂 血压 血管紧张素Ⅱ 胰岛素抵抗 调脂降压作用 

分 类 号：R259.87[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]