8例利多卡因过敏性休克死的血药浓度分析  

Study on blood drug level of 8 Lidocaine anaphylactic deaths

作　　者：卢英强[1] 宣兆艳[1] 崔佰君[1] 纪中华[1] 郭鼎[1] 

机构地区：[1]吉林大学基础医学院法医学教研室,吉林长春130021

出　　处：《中国法医学杂志》2006年第1期28-29,共2页Chinese Journal of Forensic Medicine

摘　　要：目的研究利多卡因过敏性休克死者利多卡因血药浓度及其与死因的关系。方法采用高效液相色谱法(HPLC),分别对使用利多卡因麻醉术中各项指标均正常的8例术中因利多卡因过敏性休克死者的血液和11例顺利完成手术患者的血液进行利多卡因浓度的检测,对比分析两者结果。结果 8例死者利多卡因血药浓度(1．61mg± 0．45mg／L)低于11例正常患者利多卡因血药浓度(2．44mg±0．47mg／L)。结论利多卡因过敏性休克死者血药浓度在正常值范围内,与发生过敏性休克致死无关。Objective To study the relationship between Lidocaine blood drug level and the cause of death from Lidocaine anaphylactic shock. Method Comparing and analyzing the blood drug levels by HPLC between two groups of people whose various indexes are normal before the surgery. Group 1 included 8 cases who accepted Lidocaine as anesthetic and died from Lidocaine anaphylactic shock. Group 2 included 11 cases who also took Lidocaine as anesthetic and passed the surgery smoothly. Results Lidocaine blood level of Group 1（1.61 ±0.45mg/L） is lower than that of Group 2（2.44 ±0.47mg/L）. Conclusion Lidocaine blood drug level has nothing to do with the cause of Lidocaine anaphylactic shock.

关 键 词：法医毒理学 利多卡因 过敏性休克 血药浓度 高效液相色谱 

分 类 号：D919[医药卫生—法医学]