神经干细胞增殖、迁移及分化调控机制的研究  

Mechanism of proliferation migration and differentiation of neural stem cells

作　　者：贾冬梅[1] 周亦武[1] 何光龙[1] 徐小虎[2] 

机构地区：[1]华中科技大学同济医学院法医学系,湖北武汉430030 [2]汕头大学医学院法医学教研室,广东汕头515031

出　　处：《中国法医学杂志》2006年第1期39-41,共3页Chinese Journal of Forensic Medicine

基　　金：中国博士后科学基金资助项目(2003034459);湖北省自然科学基金资助项目(2003ABA140)

摘　　要：神经干细胞能够不断增殖、迁移,并具有分化成神经元、星型胶质细胞和少突胶质细胞的能力,神经干细胞的这种特性为研究中枢神经系统退行性疾病及损伤后功能恢复奠定了基础,也为法医病理学死后时间和尸体损伤推断的研究提供了新的机遇。本文对神经干细胞的分布、生物学特性、鉴定、增殖、分化与迁移的影响因素,及其在治疗中枢神经系统疾病和法医病理学中的应用前景作一综述。Recent researches have showed that neural stem cells be isolated not only in the embryonic nervous system but also in adult nervous system. Neural stem cells have some capacity for self-renewal, migration and can differentiate into neurons, astrocyte and oligodendrocyte. This provides a basis in therapy of degenerative diseases and functional recovery of the central nervous system injury. Also helps in the study of determining the postmortem interval （PMI） and postmortem injury. Distribution, biological characteristic, identification and the factors effecting the proliferation, differentiation and migration with reference to therapy of neural stem cells and applications in forensic pathology are reviewed.

关 键 词：法医病理学 神经干细胞 巢蛋白 迁移 移植 

分 类 号：D919[医药卫生—法医学]