氧化低密度脂蛋白及其自身抗体与冠心病的相关性  

The Study of Correlation between Coronary Heart Disease and Oxidized Low Density Lipoprotein and Autoantibody

作　　者：程华[1] 马爱群[1] 周萍[1] 周朝霞[1] 强华[1] 

机构地区：[1]教育部环境与疾病相关基因重点实验室西安交通大学第一医院心内科,西安市710061

出　　处：《中国分子心脏病学杂志》2005年第1期410-414,F0003,共6页Molecular Cardiology of China

基　　金：教育部振兴行动计划资助项目

摘　　要：目的探讨氧化低密度脂蛋白(ox-LDL)及其自身抗体(ox-LDLAb)与冠心病(CHD)的相关关系,并绘制受试者工作特征曲线(ROC),评价其临床诊断意义。方法分别提取血浆和血清,用酶联免疫吸附(ELISA)方法测定血浆ox-LDL及血清ox-LDLAb浓度。结果冠心病患者ox-LDL、ox-LDLAb明显高于对照组(P<0.01),且急性心梗组(AMI)、不稳定心绞痛组(UAP)高于稳定心绞痛组(SAP)(P<0.05)。ox-LDL与ox-LDLAb)负相关。ROC曲线下面积ox-LDL为(0.805±0.039),0x-LD-LAb为(0.747±0.041),对急性冠脉综合征(ACS)有一定的鉴别力。结论血ox-LDL、ox-LDLAb水平的高低与冠心病严重程度呈正相关,可作为预测ACS和识别斑块不稳定的一项血清学指标。Objective To study correlation of Oxidized low density lipoprotein and autoantibody with coronary heart disease. By combining the clinical condition, we tried to protract ROC curve to evaluate its clinic diagnosis value. Methods Distill serum and plasma respectively, Chemiluminescent enzymelinked immunosorbent assay was used to quantitate their plasma oxidized low-density lipoprotein and serum autoantibody of oxidized low-density lipoprotein. Results The coronary heart disease group had the higher plasma ox-LDL levels and serum ox-LDLAb than control groups, and there was obvious statistic significance （P 〈 0.01 ）. The AMI and UAP groups had the higher plasma ox-LDL and serum ox-LDLAb levels than SAP groups（P 〈 0.05 ）, there was no significant difference among AMI and UAP groups, plasma ox-LDL was negative correlated to serum ox-LDLAb. The areas under ROC curve of plasma ox-LDL and serum ox-LDLAb respectively was 0.805 ± 0. 039 and 0. 747 ± 0. 041. This indicated that they have some certain diagnostic value. Conclusion plasma ox-LDL and serum ox-LDLAb levels were significant correlated to the serious degree of coronary heart disease. They can identify the unstable plaque.

关 键 词：冠心病 氧化低密度脂蛋白 抗氧化低密度脂蛋白自身抗体 斑块稳定性 

分 类 号：R541.4[医药卫生—心血管疾病]