肺炎支原体肺炎患儿体液免疫活性探讨  

Determination of humoral immunocompetence in children with Mycoplasma pneumonia

作　　者：吴志钢[1] 鞠忠玲[1] 欧阳林静[1] 滕丽珍[1] 

机构地区：[1]佛山科学技术学院附属医院儿科,广东佛山528000

出　　处：《中国热带医学》2006年第5期809-810,共2页China Tropical Medicine

摘　　要：目的探讨肺炎支原体肺炎(MPP)患儿血清补体(C)、免疫复合物(IC)、免疫球蛋白(Ig)成分含量变化和在发病机理中的作用。方法采用免疫透射比浊法和聚乙二醇沉淀比浊法对MPP患儿及正常对照组血清IgA、IgG、IgM、C4和C3含量进行检测。结果MPP患儿急性期和恢复期血清IgG、IgM、IC、C3、C4含量均明显高于正常对照组(P<0.01)。MPP重症组血清IgA、IgG、IC、C3、C4含量明显高于轻症组(P<0.01或0.05)。结论MPP患儿体液免疫活性变化在MPP发病机制中起重要作用,并对判定病情严重程度有实用价值。Objective To investigate the changes of levels of serum immunoglobulin（Ig）, immune complex（IC）, complement （C） ,and its effect in pathogenesis in chindren with mycoplasma pneumonia pneumonia（MPP）. Methods The levels of serum IgG,IgA,IgM,IC,and C4,C3 were detected in patient with MPP and in normal contral group by using turbidity method. Results The levels of serum IgG, IgM, IC, and C4, C3 in severe group were higher than those in mild group （ P 〈 0.01 or P 〈 0.05）. Conclusion The change of activity of humoral immunity play an important role in pathogenesis of children with MPP and is valuable in determining the severity of the disease.

关 键 词：肺炎支原体 肺炎 补体 免疫复合物 免疫球蛋白 

分 类 号：R563.1[医药卫生—呼吸系统]