缬沙坦对慢性心房快速起搏犬血小板和内皮功能的影响  

Effect of valsartan on platelet and endothelial function in chronic rapid atrial pacing dogs

作　　者：李悦[1] 李为民[1] 薛竟宜[1] 韩薇[1] 盛力[1] 杨树森[1] 谷宏越[1] 

机构地区：[1]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150001

出　　处：《中国实用内科杂志：临床前沿版》2006年第1期102-104,共3页

基　　金：黑龙江省自然科学基金重点项目(No.ZJY03-02);黑龙江省普通高等学校骨干教师创新能力资助计划(No.1054G027)

摘　　要：目的 探讨缬沙坦对慢性心房快速起搏诱发心房颤动（房颤）犬血小板和内皮功能的影响。方法 200l—09～2003—06对哈尔滨医科大学14只犬植入实验用心房固定频率型高频起搏器（400／min）心房快速起搏6周，建立房颤犬模型，随机分为对照组和缬沙坦组。缬沙坦组犬起搏前1周开始服用缬沙坦（30mg·kg^-1·d^-1），直至起搏结束。起搏前、后采静脉血测定二磷酸腺苷、肾上腺素、胶原、花生四烯酸诱导的犬血小板最大聚集率以及血浆血管性血友病因子（vWF）、内皮素1（ET-1）和血管紧张素Ⅱ（AngⅡ）的变化。结果 （1）起搏6周后，对照组和缬沙坦组犬血浆AngⅡ水平均明显增高，提示肾素-血管紧张素系统激活。（2）长期心房快速起搏使对照组犬二磷酸腺苷、肾上腺素、胶原和花生四烯酸诱导的血小板最大聚集率较起搏前明显增加，缬沙坦能够部分抑制起搏引起的血小板激活。（3）快速起搏使犬血浆vWF和ET-1水平明显升高，提示内皮功能受损，缬沙坦能够改善内皮功能，降低房颤犬血浆vWF和ET-1水平。结论 缬沙坦能够防治心房快速起搏引起的血小板聚集和内皮功能受损。Objective To investigate the effects of valsartan on platelet and endothelial function in atrial fibrillation dogs induced by chronic rapid atrial pacing. Methods From Sep. 2001 to Jun. 2003, 14 dogs paced at 400 bpm in the right atrium for 6 weeks were randomly divided into control group and valsartan group. The dogs in valsartan group received valsartan （ 30 mg · kg^- 1 . d^- 1 ） 1 week before rapid atrial pacing until pacing stop. The plasma von Willebrand factor （vWF） , endothelin - 1 （ ET - 1 ） , angiotensin Ⅱ （ Ang Ⅱ ） levels and blood platelet aggregation rate were measured before and after rapid atrial pacing. Results （ 1 ） Plasma Ang II level elevated significantly in both groups, indicating activation of renin - angiotensin system. （2） The maximam platelet aggregation rates by four different agonists （ Adenosine diphosphate, Epinephrine, Collagen, Arachidonic acid） increased significantly in control group dogs. To some extent, valsartan could inhibit platelet activation caused by chronic rapid atrial pacing. （3） There were significant elevations in the plasma levels of vWF and ET - 1 in control group dogs. Valsartan could meliorate endothelial function and decrease the concentrations of vWF and ET - 1. Conclusion Valsartan can inhibit platelet activation and meliorate endothelial function in chronic rapid atrial pacing dogs.

关 键 词：血管紧张素 内皮素 血小板 缬沙坦 犬 

分 类 号：R5[医药卫生—内科学]