β_2-肾上腺素能受体单核苷酸多态性与心房颤动的相关性研究  

The study on the association between β_2-adrenoceptor genetic single nucleotide polymorphisms and atrial fibrillation

作　　者：张萍[1] 郭继鸿[1] 王淑敏[2] 许原[1] 张海澄[1] 李学斌[1] 陈凤荣[3] 

机构地区：[1]北京大学人民医院心内科,北京100044 [2]北京市同仁医院,北京100053 [3]北京大学第三医院,北京100083

出　　处：《中国实用内科杂志：临床前沿版》2006年第4期595-597,共3页

基　　金：卫生部临床重点学科资助项目(20041024);北京大学心血管病211重点项目

摘　　要：目的探讨β2-肾上腺素能受体基因Arg16→Gly(46A→G)和Gln27Glu(79C→G)两种单核苷酸多态与心房颤动的相关性。方法采用等位基因特异性聚合酶链反应(PCR)的方法,对2002～2003年北京地区的218例研究对象进行两种单核苷酸多态的检测,其中孤立性房颤组58例,高血压房颤组50例,高血压组50例,健康对照组60例。结果孤立性房颤组、高血压房颤组、高血压组及健康对照各组之间两种单核苷酸多态Arg16Gly和Gln27Glu的基因型频率及等位基因频率的分布差异均无显著性,但房颤组与非房颤组相比,Gly16纯合子及Gly16等位基因的频率在房颤组显著增高(P<0.05)。结论β2-AR基因Gly16多态性与心房颤动具有相关性。Objective To determine whether the β2- adrenoceptor genetic single nucleotide polymorphisms are associated with atrial fibrillation. Methods A case -control study was performed on 218 subjects, including 58 subjects with lone atrial fibrillation, 50 subjects with atrial fibrillation and essential hypertension, 50 subjects with essential hypertension and 60 healthy controls. The β2-adrenoceptor polymorphisms at amino acids 16 and 27 were identified by allele specific polymerase chain reaction （PCR）. Results The Gly/Gly genotype as well as the Gly16 allele at amino acids 16 was significantly more common in the atrial fibrillation group than in the non -atrial fibrillation group. But there was no significant differenece in the allele frequency or the genotype frequency of the Gin27 Glu polymorphism between the two groups. In addition, the difference in the distribution of polymorphisms at amino acids 16 and 27 between the four different observed groups was not significant either. Conclusion Gly16 polymorphism of the β2-adrenoceptor overrepresenting in the atrial fibrillation group seems to be associated with atrial fibrillation.

关 键 词：心房颤动 Β2-肾上腺素能受体基因 单核苷酸多态性 

分 类 号：R5[医药卫生—内科学]