遗忘型轻度认知损害患者工作记忆事件相关电位研究  

Event-related potentials of impairment of working memory in patients with amnestic mild cognitive impairment.

作　　者：刘赛男[1] 张熙[1] 王鲁宁[1] 梁彦玲 

机构地区：[1]解放军总医院老年神经内科,北京100853 [2]聊城市东昌府医院神经内科,山东聊城252000

出　　处：《中国实用内科杂志：临床前沿版》2006年第5期743-745,共3页

基　　金：国家自然科学基金(30571600)

摘　　要：目的研究遗忘型轻度认知损伤患者的工作记忆损害机制及敏感指标。方法将2004年10月至2005年12月解放军总医院门诊和住院15例遗忘型轻度认知损害患者和15名年龄、性别、受教育年限匹配的正常老年对照参与本研究。事件相关电位检查采用视觉刺激模式,成对的简单平面图形先后呈现,受试者比较刺激对是否相同,同时记录32导脑电、正确反应率及反应时间。结果患者组与正常老年组操作行为差异无显著性。刺激相同即匹配状态下两组P300波形分布均以顶部为著,事件相关电位P300潜伏期及波幅差异无显著性(F1,28=1.0324,P=0.3183;F2,42=0.543,P=0.585)。刺激相异即冲突状态下事件相关电位N270主要分布在前头部,患者组N270潜伏期较正常老年组明显延长(F1,28=25.3264,P=0.000),波幅差异无显著性(F1,28=0.507,P=0.482)。脑电地形图与上述结果相一致。结论遗忘型轻度认知损害患者前额ERP成分N270的变化可能反映了其工作记忆中央执行系统损害。N270在检测这一损害时较P300敏感。Objective To find a sensitive index and to investigate the working memory impairment of patients with amnestic mild cognitive impairment. Methods Fifteen patients with amnestic mild cognitive impairment, 15 healthy matching aging controls were performed a matching - to - sample task while event - related potential （ ERP）, reaction time and correct rate were recorded. Subjects were required to press a button in the match condition and another button in the conflict condition. Results In the matching condition, there was no difference between the two groups in distribution （parietal lobe）, peak latency and amplitude of P300 （ F1.28 = 1. 0324, P = 0. 3183 ; F2.42 = 0. 543, P = 0. 585 ）. In the conflict condition, the distribution of N270 was fore head, and its latency of patient group were more delayed than the aging group （ F1 .28 = 25. 3264, P = 0. 000） , but its amplitude showed no significant changes （ F1.28 = 0. 507, P = 0. 482）. The result of brain mapping showed same change. Conclusion The N270 component is more sensitive than P300 to reflect the central executive function impairment of working memory in patients with amnestic mild cognitive impairment.

关 键 词：认知不协调 工作记忆 事件相关电位 N270 脑电地形图 

分 类 号：R5[医药卫生—内科学]