输血量对血源性艾滋病感染者死亡影响的研究  

Correlation of blood transfusion volume to motility rate in the patients with known duration of transfusion-acquired HIV infection in China

作　　者：卫军 张莉[2] 阮玉华[2] 杨运义 宁少萍 李建业 贾少贤 邢辉[2] 徐建青[2] 徐佳[2] 韩丽凤[2] 邵一鸣 

机构地区：[1]山西省运城疾病预防控制中心,044000 [2]北京中国疾病预防控制中心性病艾滋病预防控制中心和传染病预防控制国家重点实验室 [3]山西省夏县疾病预防控制中心 [4]山西省芮城疾病预防控制中心

出　　处：《中华传染病杂志》2006年第2期106-108,共3页Chinese Journal of Infectious Diseases

基　　金：国家十五科技攻关课题项目(2001BA705B02);国家自然科学基金资助项目(30170823)

摘　　要：目的了解能够确认输血感染时间的人类免疫缺陷病毒（HIV）感染者生存情况及其影响因素.方法 1999年1月至2003年12月,从我国中部某农村地区HIV/艾滋病（AIDS）疫情监测和报告系统中发现符合本研究条件的76例能够确认输血感染时间的HIV感染者.调查该人群社会人口学、输血和死亡情况.统计分析采用Cox比例风险回归模型.结果至2003年12月,在调查对象76例中,死亡24例,病死率为45.64/1000人年,中位生存时间为8.3年.在多因素Cox比例风险回归模型分析中,输血量（危险比为3.12,95% CI：1.18～8.25;P=0.0218）同输血人群HIV感染者死亡的关系差异有统计学意义.结论输血量大可能是血源性感染HIV患者死亡的危险因素.Objective To investigate the association of blood transfusion volume with early death among recipients with known duration of infection in rural central China. Methods From Janu ary 1, 1999 to December 30, 2003, 76 individuals with duration of blood transfusion who met the study criterion had been found to be infected in the HIV/AIDS notified system in rural of Yuncheng Prefecture of Shanxi Province, China. A retrospective study was conducted to investigate Socio-demographic characteristics, transfusion volume, and mortality. Cox＇ proportional hazard regression model was used to analyze the data. Results By December 30, 2003, among 76 subjects with transfusion-acquired HIV infection, 24 recipients had died. Mortality rate and median survival was 45.64 and 8.3 per 1000 person years, respectively. Transfusion volume （HR=3. 12, 95% CI： 1.18-8.25; P=0. 0218） was significantly associated with mortality in recipients in the multiply Cox＇ proportional hazard regression model. Conclusions This study suggests that more units of transfusion in recipients with known duration of HIV infection can influence time to death in recipients in China.

关 键 词：输血 时间因素 获得性免疫缺陷综合征 死亡原因 存活率 

分 类 号：R512.91[医药卫生—内科学] R181.36[医药卫生—临床医学]