艾亚林缓释膜辅助治疗中重度牙周炎的临床疗效  

Clinical effects of local application of Minocycline hydrochloride sustained-release pellicle in moderate-severe periodontitis

作　　者：笪海芹[1] 向晓明[2] 黄忠锁 丁晓红[1] 

机构地区：[1]合肥市口腔医院牙周科,安徽合肥230001 [2]武汉大学口腔医院牙周黏膜科

出　　处：《临床口腔医学杂志》2006年第5期295-297,共3页Journal of Clinical Stomatology

摘　　要：目的:评价艾亚林缓释膜局部应用辅助治疗中重度牙周炎的临床疗效。方法:用随机、单盲、自身对照方法研究艾亚林缓释膜置于深牙周袋内辅助牙周基础治疗的临床疗效,以单纯基础治疗为对照,观察基线、第2周及第6周菌斑指数(PLI)、龈沟出血指数(SBI)、牙周探诊深度(PD)及用药后反应。结果:除PLI外,两组第2周及第6周的SBI、PD都较基线时有改善(P<0.05);治疗组第6周较第2周除PLI略有反弹外,其余指标皆进一步改善(P<0.05);在两个观察时段,治疗组较对照组在SBI、PD方面,皆有显著性差异(P<0.01),但PLI两组间无差异;未发现用药后不良反应。结论:艾亚林缓释膜局部应用辅助治疗中重度牙周炎有较好的临床疗效。Objective： To evaluate the clinical effect of local application of minocycline-HCL sustained-release pellicle as the auxiliary treatment of moderate-severe chronic periodontitis. Method：A randomized, blind, split-mouth study was designed. Following initial therapy minocycline-HCL S. R, pellicle was administered into the periodontal pocket of treatment sides at baseline, but the contbol sides had no drug. Standard clinical indices （including PLI, SBI and PD） and response to S. R. pellicle were evaluated at basedline,week 2 and week 6. Result：Except PLI, indices of both groups showed significant improvement （P〈0. 05） on week 2 and week 6 compared with baseline. In the test group, all indices improved significantly at week 6 than week 2 except PLI. Sides treated with minocycline-HCL S. R. pellicle always produced statistically significantly reduction （P〈0.01） of SBI and PD than the control sides, but PLI of the two groups showed no difference. No fide-effect had been found after administered S. R. pellicle. Conclusion：Administration of the local drug delivery system of minocycline-HCL S. R. pellicle as the auxiliary treatment of moderate-severe chronic periodontitis could get good clinical results.

关 键 词：牙周炎 盐酸米诺环素 局部药物治疗 

分 类 号：R988.2[医药卫生—药品]