支持细胞中促卵泡素信号通路研究进展  

Review on FSH Signaling in Sertoli Cells

作　　者：高小燕[1] 孙燕[1] 张家骅[1] 

机构地区：[1]西南大学重庆市牧草与草食家畜重点实验室,重庆400716

出　　处：《动物医学进展》2006年第5期1-5,共5页Progress In Veterinary Medicine

基　　金：教育部博士专项基金(20040625004)

摘　　要：支持细胞在精子生成过程中起重要作用,支持细胞的数量决定睾丸大小、生精细胞数量以及最终生成精子数量。促卵泡素作为保证雄性生育能力的重要激素之一,通过与支持细胞上的促卵泡素受体结合,诱导5种信号途径,导致支持细胞中各类转录因子被激活,引起基因表达发生变化,从而保证生精细胞顺利发育成精子。文章主要围绕支持细胞中促卵泡素信号途径,及其对细胞发育过程中相关基因表达的影响等方面进行了综述。The process of spermatogenesis is dependent upon the somatic Sertoli cells. The number of Sertoli cells determines testicular size, germ cell numbers per testis and spermatozoa output. Follicle-stimulating hormone （FSH） is required to obtain full reproductive potential. In the testis, when FSH interacts with the receptor,there are more than 5 pathways are induced, which play important roles in simulating kinds of transcription factors. As a result, the gene expression in Sertoli cells undergoes a series of changes which appears to be required for spermatogenesis, In this review, we discussed FSH signaling pathways and the gene expression changes during Sertoli cell development and spermatogenesis.

关 键 词：支持细胞 促卵泡素 信号转导 精子发生 基因表达 

分 类 号：S852.21[农业科学—基础兽医学] S857.21[农业科学—兽医学]