血尿酸和胆红素水平与冠状动脉病变严重程度的关系  

Relationship between the level of serum uric acid,bilirubin and the severity of coronary artery lesion

作　　者：杨锐英[1] 李晓英[1] 贾绍斌[1] 张金莉[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2006年第5期332-334,共3页Ningxia Medical Journal

摘　　要：目的探讨血尿酸、胆红素水平与冠状动脉病变严重程度的关系。方法回顾性分析353例选择性冠状动脉造影的患者,按冠状动脉狭窄程度分为冠状动脉造影阴性组、单支病变组、双支病变组和多支病变组,分析不同组别血尿酸和胆红素水平的差异及其与冠状动脉病变严重程度的相关性。结果冠状动脉造影阳性组血尿酸水平明显高于阴性组,且血尿酸升高与冠状动脉狭窄程度呈正相关;总胆红素、间接胆红素水平明显低于阴性组(P<0.05),且总胆红素、间接胆红素降低与冠状动脉狭窄程度呈负相关;直接胆红素水平在各组间差异无显著性(P>0.05)。结论血尿酸升高,血清总胆红素、间接胆红素水平降低与冠状动脉狭窄程度密切相关,可能在冠心病的发生发展中起着一定的作用。Objective To explore the relationship between the level of serum uric acid （SUA）, bilirubin and the severity of coronary artery lesion. Methods Three handreds and fifty- three patients were selected for coronary angiography （CAG） and analyzed retrospectively.They were divided into four groups according to the numbers of stenosed branch. The difference in level of SUA and Bilirubin were compared in four groups, and the correlation of them with the coronary artery score and numbers of stenosed branch were analyzed in four groups, Results The level of SUA, total bilimbin（TBIL） , indirect bilimbin（IBIL） were significantly difference between the subgroups of CHD and the control group（ P 〈 0.05）. The level of SUA positively related with the severity of CHD. The level of TBIL, IBIL. negatively related with it. Therefore, the level of direct bilirubin（DBIL） was no significantly difference between the subgroups of CHD and the control group （ P 〉 0.05）. Conclusion The level of elevated 5UA, dropped TBIL, IBIL. are closely related with the severity of CHD. Perhaps they play a particular role in the genesis and progress of CHD.

关 键 词：尿酸 胆红素 冠状动脉造影术 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]