血脉通颗粒治疗颈动脉粥样硬化的临床研究  

Clinical Study on Effect of Xuemaitong Granule on Cervical Artherosclerosis

作　　者：张琪[1] 张斌霞[1] 蒋晓霞[1] 史兵伟[1] 

机构地区：[1]江苏省常州市中医院,江苏常州213003

出　　处：《南京中医药大学学报》2006年第3期162-164,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省中医管理局资助项目(9970)

摘　　要：目的观察血脉通颗粒对颈动脉粥样硬化的作用机理。方法采用彩色多谱勒超声技术从高血压或高血脂患者中检测出77例颈动脉硬化的病人,随机分成治疗组和对照组,治疗组采用血脉通颗粒10 g,每日3次,口服;对照组采用舒降之20 mg,每晚顿服、疗程均为6个月。观察治疗前后增厚的颈动脉内膜中层与斑块消退的情况、血脂变化、MDA、SOD、MMP-1及上述药物的不良反应。结果2组病人颈动脉内膜中层增厚未进一步发展,斑块有所消退,但治疗前后无显著性差异,治疗组治疗前后TG、LPa、ox-LDL、MDA、基质金属蛋白酶MMP-1均有明显降低,HDL-C、SOD升高明显,统计学有显著性差异。2组无明显不良反应。结论血脉通颗粒可有效调控血脂,改善血管内皮功能、稳定斑块。OBJECTIVE To observe the mechanism of Xuemaitong Granule on cervical artherosclerosis. METHOD Doppler ultrasound technique was adopted to choose 77 cervical artherosclerosis patients from those with hypertension or hyperlipemia, which were divided randomly into a treatment group and a control group, treated with Xuemaitong Granule （10 grams at a time, three times daily） and Simvastatin（20 mg/qn） respectively for 6 months. RESULT In both groups, the thickening of the middle layer of cervical endarterium did not develop further and the plaques were resolved, but with no marked difference as compared with the conditions before the treatment. In the treatment group, TG, LPa, ox- LDL, SOD, MDA and MMP- 1 dropped greatly and HDL- C increased greatly, with marked statistical significance. No undesirable reactions were found in both groups. CONCLUSION Xuemaitong Graunle can effectively control blood lipid, improve the function of blood vessel endodermis and prevent the development of the plaques.

关 键 词：颈动脉粥样硬化 血脉通颗粒 基质金属蛋白酶 

分 类 号：R259.434[医药卫生—中西医结合]