新型2-乙内酰硫脲衍生物的合成与表征  

Synthesis and Characterization of Novel 2-Thiohydantoin Derivatives

作　　者：孙卫东[1] 高飞飞[2] 张锁秦[2] 李耀先[2] 张广良[2] 

机构地区：[1]赤峰学院化学系 [2]吉林大学化学学院,长春130021

出　　处：《应用化学》2006年第5期538-542,共5页Chinese Journal of Applied Chemistry

摘　　要：通过异氰酸酯法合成一系列新型2-乙内酰硫脲衍生物,应用1H NMR、13C NMR、IR测试技术对分子的结构进行了表征;初步测定了化合物的除草活性;对构效关系进行了分析。结果表明,在乙内酰硫脲5位上含有甲基取代基的化合物的除草活性要高于5位上没有取代基的化合物。最大的芽抑制率为56.5%,最大的根抑制率为53.8%。2-乙内酰硫脲衍生物可以作为一类新的农药先导化合物。Novel 2-thiohydantoin derivatives were synthesized, and the structures of the title compounds were confirmed by ^1H NMR, ^13C NMR, and IR. The preliminary biological tests of the tide compounds were carried out. The structure-activity relationship was analyzed from structure characteristic and substituent effect. The results show that 5-methyl-2-thiohydantoin derivatives exhibit higher biological activity than those without 5-methyl. The maximum inhibiting rate is 56. 5% （sprout） and 53.8% （root）. 2-Thiohydantoin derivatives can be made into novel pesticide precursor compounds.

关 键 词：乙酰乳酸合成酶 磺酰脲 乙内酰硫脲 合成 

分 类 号：O621.3[理学—有机化学] TQ457.2[理学—化学]