^(18)F-FDG符合显像诊断梗死心肌活力的实验研究  

^(18)F-FDG coincidence imaging diagnosis of viability of infarction myocardium

作　　者：许长德[1] 陈绍亮[1] 姚瑞敏[1] 张庆勇[1] 石洪成[1] 

机构地区：[1]复旦大学附属中山医院核医学科,上海200032

出　　处：《核技术》2006年第5期372-375,共4页Nuclear Techniques

摘　　要：将6只20kg的小型猪制作心肌梗死模型,进行心肌99Tcm-甲氧基异丁基异腈(99Tcm-sestamibi,99Tcm-MIBI)血流灌注显像确定梗死区,用18F-脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)观察空腹与糖负荷图像的差别,确定心肌坏死或存活区。制作模型前进行自身对照形成对照组。并进行B超心功能检查。结果显示:心肌梗死区大部分心肌没有活力,99Tcm-MIBI和18F-FDG都没有摄取。空腹时有部分心肌显影,糖负荷时该区域显影程度减轻。The objective of the work is to observe the role of ^99Tc^m-sestamibi perfusion imaging and coincidence imaging with ^18F-FDG for detecting viability of infarct myocardum in miniswine model. Six minipigs with circumflex branch ligation for the myocardial infarction underwent excising and resting myocardial pcrfusion imaging with ^99Tc^m-MIBI by using single photon emission computed tomography （SPECT）and fast and glucose-injection coincidence imaging with ^18F-FDG They also underwent the imaging before operation as a normal control group. The region of myocardial infarction of the model was found no uptake of the ^99Tc^m-MIBI and ^18F-FDG Part myocardium can be imaged in fast state, and after injecting SSF-FDG the images in this region get fainter. It is concluded that the coincidence imaging with SSF-FDG is better to diagnose the viability of infarct myocardium, and fast and glucose stress can display viability of severe ischmia myocardium.

关 键 词：^18F-脱氧葡萄糖 ^99TC^M-甲氧基异丁基异腈 心肌活力 

分 类 号：R817.4[医药卫生—影像医学与核医学]