双金解毒胶囊对吗啡依赖性动物的药效学研究  

STUDY OF SHUANGJINJIEDU CAPSULES′PHARMACODYNAMICS IN THE MORPHINE-DEPENDENT ANIMALS

作　　者：贾庆忠[1] 裴庭梅[1] 陈雪彦[1] 郭鸣放[1] 苗庆峰[1] 张永健[1] 

机构地区：[1]河北医科大学基础医学院药理学教研室,河北石家庄050017

出　　处：《河北医科大学学报》2006年第3期192-195,共4页Journal of Hebei Medical University

摘　　要：目的观察双金解毒胶囊对吗啡依赖性动物模型的脱毒药效。方法以剂量递增法造成动物对吗啡的依赖性,用纳洛酮催促戒断、自然戒断模型上,以盐酸苯氨咪唑啉作为阳性对照,评价双金解毒胶囊对吗啡依赖动物戒断症状的抑制作用。结果在吗啡依赖大鼠纳洛酮催促戒断模型,双金解毒胶囊1.6 g和3.2 g/kg,均可显著控制大鼠的戒断症状(P<0.01),对大鼠体质量的恢复,0.8 g1、.6 g和3.2 g/kg组均较盐水对照组为快(P<0.01)。在吗啡依赖大鼠自然戒断模型,双金解毒胶囊1.6 g和3.2 g/kg组自然戒断症状显著较盐水对照组为轻(P<0.01),体质量恢复亦较快(P<0.01)。双金解毒胶囊0.4 g、0.8 g和1.6 g/kg均可显著改善吗啡依赖猴的戒断症状(P<0.05与0.01)。结论双金解毒胶囊对吗啡依赖大鼠和猴有脱毒作用。Objective To study the effects of Shuangjinjiedu（SJJD） capsules on reducing the withdrawal symptoms in morphine-dependent animals. Methods The models of morphine- dependent animals were created by an increasing dose of morphine. Effects of SJJD capsules on reducing the withdrawal symptoms in morphine-dependent rats and Macaca rhesus were evaluated by two models： withdrawal model induced by aloxone hydrochloride and natural withdrawal model. Aniline hydrochloride imidazole was used as positive control drug. Results For the withdrawal model of morphine-dependent rats induced by naloxone hydrochloride, SJJD 1.6g and 3.2 g/kg groups markedly reduced withdrawal symptoms（ P 〈0.01） ; The weight of rat in SJJD 0. 8 g, 1.6 g and 3.2 g/kg groups recovered rapidly （ P 〈0.01）. For the natural withdrawal rats model, SJJD 1.6 g and 3. 2 g/kg groups markedly reduced withdrawal symptoms and the weight of rats markedly improved. SJJD 0.4 g,0.8 g and 1.6 g/kg groups markedly reduced withdrawal symptoms of Macaca rhesus. Conclusion SJJD capsules can markedly attenuate experimental withdrawal symptoms of opiates dependent rats and Macaca rhesus.

关 键 词：双金解毒胶囊 吗啡依赖 物质戒断综合征 

分 类 号：R595.5[医药卫生—内科学] R969.4[医药卫生—临床医学]