H5N2与H5N1禽流感油乳灭活疫苗免疫鹅群对H5N1流行株攻毒的保护效力及母源抗体对免疫效力的干扰  

Comparison of Protective Efficacy of Geese Immunized with H5N2 and H5N1 Subtype Inactivated Oil-emulsion Vaccine to Challenge of H5N1 AIV and Analysis the Effects of Maternal Antibody on Immune Resposes

作　　者：张评浒[1] 唐应华[1] 薛峰[1] 曹永忠[1] 仇旭升[1] 孙学辉[1] 刘小文[1] 高崧[1] 刘秀梵[1] 

机构地区：[1]扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州225009

出　　处：《中国兽医学报》2006年第3期268-270,274,共4页Chinese Journal of Veterinary Science

基　　金：国家科技攻关计划项目(2004BA519A02)

摘　　要：应用H5N2和H5N12种类型禽流感油乳灭活疫苗分别免疫鹅群,观察比较了二者对H5N1型高致病性禽流感病毒的攻毒保护效力。结果表明,在同等剂量免疫条件下,从发病率、死亡率和泄殖腔排毒规律3项指标综合评价来看,H5N1灭活苗水禽免疫组对高致病性禽流感H5N1流行株攻毒的保护效率较H5N2灭活苗理想,且水禽禽流感母源抗体对灭活苗免疫具有一定的干扰作用。In this study ,protective efficacy of Geese at 11 days old Immunized with H5N2 and H5N1 subtype inactivated oilemulsion vaccine to the challenge of H5N1 AIV was evaluated. According to the morbidity, mortality and protective efficacy, the protective effects of flocks immunized with H5N1 is better than that of H5N2 under the same immune close and the presence of maternal antibody could interfere with bird＇s active immunization.

关 键 词：禽流感 H5亚型油乳灭活疫苗 鹅 免疫 攻毒 

分 类 号：S852.4[农业科学—基础兽医学] S858.33[农业科学—兽医学]