3种血清学指标与系统性红斑狼疮性肾炎的关系  

Correlations between several autoantibodies with nephritis in systemic lupus erythematosus

作　　者：李彤[1] 文锐[1] 曾衡军[1] 

机构地区：[1]南华大学附属第一医院肾内科,湖南衡阳421001

出　　处：《中国现代医学杂志》2006年第9期1396-1398,共3页China Journal of Modern Medicine

摘　　要：目的探讨3种血清学指标,抗双链DNA抗体(anti-dsDNA)、抗核糖体P蛋白抗体(anti-P)和抗脂蛋白酶抗体(anti-LPL)与系统性红斑狼疮(SLE)性肾炎的关系。方法分析该院自2001年以来71例SLE患者各主要相关血清学指标与SLE肾炎的关系。结果SLE肾炎anti-dsDNA、anti-P和anti-LPL有较高的阳性率,而且它们之间存在较高的协同相关性(P<0.05)。结论anti-LPL的升高和anti-LPL与anti-P的协同相关性,及anti-LPL与anti-dsDNA的协同相关性可以作为诊断SLE肾炎的依据。[Objective] To explore the relationship between several serological autoantibodies with nephritis in system lupus erythematosus （SLE）. [Methods] The data mainly obtained by consulting the patient from March, 2001 to July, 2005; 71 SLE patients were collected and analyzed. The comparison nephritis and non-nephritis patients in the prevalence of different speeifieities was performed. [Results] Anti-dsDNA, anti-ribosomal P protein （anti-P）, and antibodies to lipoprotein lipase （anti-LPL） were more likely appeared in the sera of SLE nephritis patients than of non-nephritis patients; and there are strong synergistic effects of anti-LPL and anti-P, and of anti-dsDNA and anti-P （P 〈0.05）. [Conclusions] Anti-LPL, the synergistic effects of anti-LPL and anti-P, and of anti-LPL, anti- dsDNA could be practiced as criteria for SLE nephritis diagnosis.

关 键 词：抗脂蛋白酶抗体 抗核糖体P蛋白抗体 抗双链DNA抗体 狼疮性肾炎 

分 类 号：R593.242[医药卫生—内科学]