β族胸腺素研究进展  

Advances of β-thymosins

作　　者：王春卉[1] 宋海峰[1] 刘秀文[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《中国新药杂志》2006年第8期580-584,共5页Chinese Journal of New Drugs

基　　金：国家863计划资助(2003AA2Z347B)

摘　　要：胸腺素(Thymosins)主要是由胸腺产生的一种淋巴细胞生长因子,目前β族胸腺素(β-Thymosins, Tβ)越来越引起人们的关注。尽管其分子水平作用机制尚未阐明,但Tβ却与人类的许多生理及病理过程关系密切。随着研究的进一步深入,Tβ家族的潜在临床应用价值将被开发,这对某些疾病的诊断、治疗及预后均具有重要意义。现详细综述近5年国内外关于Tβ的最新研究进展,包括其与肌动蛋白、肿瘤、炎症反应、细胞调亡、血管生成及创伤愈合的关系。Scientists are increasingly paying attentions to the investigations of β-thymosins （Tβ） as a result of its close relationship with many physio- and patho-processes of human being. With more understanding of the mechanism of Tβ bioactivities at the molecular level, the Tβ may serve as a potent tool in the diagnosis, treatment and prognosis of certain diseases. This review presented advances of the Tβ in the passing 5 years, including its intraeellular roles in actin, neoplasm, inflammatory reaction, apoptosis, angiogenesis and wound healing.

关 键 词：β族胸腺素 肌动蛋白 肿瘤转移 炎症反应 细胞凋亡 血管生成 创伤愈合 

分 类 号：R979.5[医药卫生—药品]