美洛昔康口腔崩解片的制备及质量控制  

Preparation and quality control of meloxicam oral disintegrating tablets

作　　者：奚炜[1] 熊长友[1] 张书银[1] 彭官良[1] 

机构地区：[1]宜昌市第一人民医院,宜昌443000

出　　处：《中国新药杂志》2006年第8期610-612,共3页Chinese Journal of New Drugs

摘　　要：目的:制备美洛昔康口腔崩解片并对其进行质量检查。方法:采用正交设计法确定最佳处方,以甘露醇为主要辅料制备美洛昔康口腔崩解片,并对崩解时限、口感、溶出度进行了考察。结果:最佳处方为1 000片用交联聚乙烯吡咯烷酮(PVPP)20 g,甘露醇140 g,聚乙烯吡咯烷酮(PVP)3．0 g,聚山梨酯-80 0．2 g,崩解时限小于30 s。口腔崩解片在10 min左右完全溶出,而普通市售片在45 min溶出80％。结论:本研究制备的美洛昔康口腔崩解片为快速崩解型片剂,累积溶出度快干市售片。Objective：To prepare meloxicam oral disintegrating tablets. Methods： The formulation of the oral disintegrating tablets was optimized using an orthogonal method. The disintegration, taste and dissolution were assessed. Results： The optimal excipients for 1 000 tablets were composed of mannitol 140 g, PVP 3.0 g, PVPP 20 g, and Tween-80 0. 2 g. The tablets had disintegration times as low as 30 seconds and the dissolution around 10 minutes. Conclusion： The oral disintegrating tablets can be used for geriatric and pediatric population.

关 键 词：美洛昔康 口腔崩解片 质量评价 

分 类 号：R944.9[医药卫生—药剂学] R971.1[医药卫生—药学]