氟苯尼考在九孔鲍体内的药代动力学初步研究  

A preliminary study on pharmacokinetics of florfenicol in Haliotis diversicolor supertexta

作　　者：徐力文[1] 廖昌容[1] 王瑞旋[1] 王江勇[1] 陈毕生[1] 

机构地区：[1]中国水产科学院南海水产研究所,广东广州510300

出　　处：《台湾海峡》2006年第2期216-221,共6页Journal of Oceanography In Taiwan Strait

基　　金：广东省重大科技招标项目(2KB05301N);广东省自然科学基金资助项目(04001264)

摘　　要：初步研究了新型抗菌兽药氟苯尼考(florfenicol)在健康九孔鲍体内的药代动力学特征;建立了高效液相色谱法(HPLC)检测鲍血淋巴中氟苯尼考含量的可靠方法,平均回收率为85.69%,最低检测限0.05μg/cm3.以20×10-6(m/m)剂量对九孔鲍腹足单次肌注,血药浓度-时间数据用非房室模型的统计矩原理(SMT)处理后的主要药代动力学参数为:血药浓度-时间曲线下面积(AUC)为21.25mg/(h.dm3),平均滞留时间(MRT)为2.41h,清除率(C lB)为0.94dm3/(kg.h),稳态表观分布容积[Vd(ss)]为2.27dm3/kg,消除半衰期(t1/2β)为3.61h.结果显示氟苯尼考在九孔鲍体内吸收良好,分布广泛,代谢消除快.Pharmacokinetics of florfenicol were investigated in healthy Haliotis diversicolor supertexta after single intramusclar injection （ IM）, and florfenicol concentration in the hemolymph of abalones was determined by PHLC. The drug concentration-time data after single IM. in the abalones were analyzed by non-compartment methods based on statistical moment theory （SMT）. The main pharmacokinetic parameters were obtaimed as follows ： AUC was 21.25 mg/（ h ·dm^3 ） , MRT, 2. 41 h, ClB, 0.94dm^3/（kg · h）, Vd（ss） ,2. 27dm^3/kg and t1/2β,3.61h. Average recovery was 85.69% and the test limitation was 0.05 μg/cm^3. The result suggested that florfenicol in H. diversicolor supertexta was completely, absorbed and distributed and it eliminated quickly by metabolism.

关 键 词：九孔鲍 氟苯尼考 药代动力学 高效液相色谱法 

分 类 号：S948[农业科学—水产养殖]