转铁蛋白受体、铁蛋白及铁调节蛋白-1 mRNA在铁缺乏胎儿胎盘中的表达  

Expressions of Transferrin Receptor mRNA,Ferritin Receptor mRNA and Iron Regulatory Protein 1 mRNA in the Placentas Complicated with Fetal Iron Deficiency

作　　者：刘春艳[1] 刘玉峰[1] 张曙光[1] 

机构地区：[1]郑州大学第一附属医院,郑州450052

出　　处：《实用儿科临床杂志》2006年第10期609-610,612,共3页Journal of Applied Clinical Pediatrics

基　　金：河南省科技厅自然科学项目资助(111010900)

摘　　要：目的探讨铁转运相关蛋白mRNA在胎儿铁缺乏(ID)胎盘中的表达。方法根据脐血血清铁蛋白(SF)水平将研究对象分为ID组和铁充足(IS)组。采用RT-PCR方法测定两组胎盘转铁蛋白受体(TfR)、铁蛋白(Fn)和铁调节蛋白-1(IRP-1)mR- NA表达情况。结果 1．ID组TfR mRNA为1 10±0．26,明显高于IS组(t=0．028 P<0.05);2．ID组Fn mRNA为0．304± 0 095,明显低于IS组(t=0.014 P<0．05);3．ID组IRP-1 mRNA为0．278±0.073,与IS组无统计学差异(t=0．086 P> 0．05);4．胎盘TfR mRNA和脐血SF自然对数呈明显负相关(r=0.558 P<0 05),而Fn mRNA与脐血SF自然对数呈明显正相关(r=0．502 P<0．05)。结论胎儿ID时胎盘TfR mRNA表达升高,Fn mRNA减少,IRP-1 mRNA无明显变化,可最大程度地保证胎儿铁供应的相对恒定。Objective To investigate the expressions of transferrin receptor（TfR） mRNA, ferritin （Fn） mRNA and iron regulatory protein 1 （IRP - 1） mRNA in the placentas complicated with fetal iron deficiency（ID）. Methods Depending on the cord SF, the subjects were divided to fetal ID group and fetal iron sufficient （IS） group. TfR mRNA, Fn mRNA and IRP - 1 mRNA in placentas were measured by RT - PCR. Results 1. The expression of TfR mRNA in ID group was 1.10±0.26, it was significantly higher than that in IS group （t=0.028 P〈0.05）; 2. Fn mRNA in ID group was 0.304±0.095, it was significantly lower than that in IS group （t=0.014 P〈0.05）; 3. The expression of IRP - 1 mRNA in ID group was 0.278±0.073, there was no difference in two groups （t=0.086 P〉0.05）; 4. TfR mRNA and Fn mRNA correlated with fetal IS respectively. Conclusion Fetal ID induces highly expressed TfR mRNA and lower level of Fn mRNA to furthest satisfy the iron need for fetus.

关 键 词：铁缺乏 胎盘 转铁蛋白受体 铁蛋白 铁调节蛋白-1 信使核糖核酸 

分 类 号：R714.5[医药卫生—妇产科学]