病毒性脑炎患儿脑脊液和血清S-100β蛋白测定的意义  

Clinical Significance of Detection of S - 100β Protein in Cerebrospinal Fluid and Serum of Children with Acute Viral Encephalitis

作　　者：曹玉红[1] 张光运[2] 张国成[1] 曹艳华[3] 杨欣伟[1] 钱新宏[1] 沈青[1] 

机构地区：[1]第四军医大学西京医院儿科,西安710032 [2]第四军医大学西京医院神经内科,西安710032 [3]济南军区总院儿科,济南250031

出　　处：《实用儿科临床杂志》2006年第10期622-623,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨病毒性脑炎(病脑)患儿脑脊液(CSF)和血清S-100β蛋白变化的临床意义。方法采用酶联免疫吸附试验双抗体夹心法对36例病脑和20例无神经系统疾病而需外科手术的腰麻患儿CSF和血清S-100β蛋白进行测定。比较昏迷组与无昏迷组、惊厥组与无惊厥组、有后遗症组与无后遗症组CSF和血清S-100β蛋白水平的差异。结果 1．病例组和对照组CSF 中S-100β蛋白水平分别为(0.641±0．390)、(0．037±0．014)μg/L,血清S-100β蛋白水平分别为(0．444±0．257)、(0．023± 0．009)μg/L,两组CSF、和血清S-100β蛋白水平均有显著性差异(P<0．01,0．05);昏迷组CSF和血清S-100β蛋白均显著高于无昏迷组(P均<0 01);惊厥组CSF和血清S-100β蛋白水平均高于无惊厥组(P均<0．01);后遗症组CSF和血清S-100β蛋白均高于无后遗症组(P均<0．01)。结论病脑患儿CSF和血清S-100β蛋白水平与疾病严重程度相关,检测病脑患儿S-100β蛋白水平的变化,有助于判定脑组织受损的严重程度及评估患儿的预后。Objective To explore the changes of S - 100β protein in cerebrospinal fluid and serum of children with viral encephalitis and its clinical significance. Methods The levels of S - 100β protein of cerebrospinal fluid and serum of 36 children with viral encephalitis and 20 lumbar anesthesia children without central nervous system diseases were measured by enzyme - linked immunosor bent assay. Differences in the levels of cerebrospinal fluid and serum S - 100β protein between children with and without coma, with and without convulsion, with and without sequelae in the ease group were compared. Results S - 100β protein levels of eerebroepinal fluid in the ease group and control group were （0.641±0.390） and （0.037±0.014）μg/L（P 〈 0.01）. Serum S - 100β protein levels in the case group and control group were （0.444±0.257） and （0.023±0.009）μg/L（P 〈 0.05）.The cerebrospinal fluid and serum S - 100β protein levels of children with coma were significantly higher than those of children without coma （all P 〈 0.01）, and those of children with convulsion were higher than those of children without convulsion （all P 〈 0.01）. The cerebrospinal fluid and serum S - 100β protein levels of children with sequelae were significantly higher than those of children without sequelae （all P 〈 0.01）. Conclusions The cerebrospinal fluid and serum S - 100β protein levels of children with viral encephalitis relates to degree of severity. Detection of S - 100β protein of children with viral encephalitis contributes not only to assess the severe degree but also to predict their prognoses.

关 键 词：S-100Β蛋白 脑脊液 血清 病毒性脑炎 小儿 

分 类 号：R725.1[医药卫生—儿科]