瘦素、IGF—I和胰岛素与新生儿生长发育关系的研究  

Study on the changes of the serum leptin levels and their reationship with IGF-I, insulin in growth development of neonate

作　　者：郑义敏[1] 林英[1] 李腾[1] 刘小红[1] 

机构地区：[1]广东省深圳市儿童医院新生儿科,广东深圳518026

出　　处：《海南医学》2006年第6期51-52,共2页Hainan Medical Journal

摘　　要：目的测定新生儿期血清瘦素、胰岛素样生长因子-I(IGF-I)、胰岛素水平变化,了解其间关系,探讨瘦素对新生儿期生长发育的影响。方法采用放射免疫分析法检测60例健康足月儿脐静脉血(脐血组)、生后4～6天(早期新生儿组)、25～28天(晚期新生儿组)静脉血瘦素、IGF-I、胰岛素水平。结果早期新生儿组血清瘦素水平(0.61±0.46)ug/L明显低于脐血组(8.31±6.70)ug/L和晚期新生儿组(1.64±0.54ug/L)其下降值与此期间血清IGF-I的下降值呈显著正相关,而与胰岛素的增长值、体重等的下降值无相关性。晚期新生儿血清瘦素水平呈逐渐升高趋势,其增长值与血清IGF-I和胰岛素的增长值、体重的增长值呈显著正相关。结论新生儿期血清瘦素水平的动态变化与体重,血清IGF-I、胰岛素等存在一定相关性,提示瘦素在新生儿生长发育和能量平衡方面起重要作用。Objective To measure the dynamic changes of serum leptin, insulin-like growth faetor（IGF-I） and insulin levels in newborns and to explore their relationship with neonatal growth ang development, Methods The serum levels of leptin, IFG-I and insulin in 60 healthy neonates were measured by the method of radioimmunoassay at birth, 4-6 days and 25-28days old. Results The serum leptin levels at 4-6 daysof newborns were （0.61±0.46） ug/L, which were significantly lower than those at birth （8.31±6.70）ug/L, also significantly lower than those at 25-28 days of life （1.64±0.54） ug/L. The rise of serum leptin levels correlated with the body weight gain as well as with the rise of IGF-I and insulin levels occurred between 4-6 and 25-28 days, The descentof serum leptin levels didn＇t correlate with body weight loss, neither with the reduced levels of insulin occurred between at birth and at 4-6 days old. Conclusions The changes of leptin levels in the newborn period showed positive correlation with neonatal weight, it was suggested the leptin play an important role in regulation of weight and energy homeostasis in neonates and may be a regulative factior in neonatal growth with the IGF-I and insulin.

关 键 词：瘦素 胰岛素生长因子-1 胰岛素 新生儿 

分 类 号：R722[医药卫生—儿科]