柑桔素对硝苯地平光降解稳定作用的研究  

Effect of Naringenin on Photo stability of Nifedipine

作　　者：李丰文[1] 

机构地区：[1]中国药科大学

出　　处：《中国药科大学学报》1996年第3期155-158,共4页Journal of China Pharmaceutical University

摘　　要：在３种缓冲溶液和４种ｐＨ值情况下研究了日光照射下柑桔素对硝苯地平光降解的影响。硝苯地平在ｐＨ７．５６，６．３９，５．５５和３．９９缓冲溶液中的半衰期（ｔ１／２）分别为７．４，７．６，７．１和６．０ｈ；当在相同缓冲溶液中加入等量柑桔素时，硝苯地平的ｔ１／２分别为４．１，１１．８，７．３和６．１ｈ；各种溶液中，硝苯地平的光解均为一级动力学过程。在和柑桔素混合时，硝苯地平最稳定的ｐＨ值是６．４左右。Photo stability of nifedipine(NF) and effect of naringenin(NR) on photodecomposition of NF under three buffer solutions and four pH values were presented.When pH values were 7.56, 6.39 ,5.55,3.99, t 1/2 of NF were 7.4,7.6,7.1,6.0 h respectively;It seems that the pHs and the types of buffer do not significantly affect the photodegradation rate of NF.However, t 1/2 of NF buffer solutions containing same amount of NR were 4.1,11.8,7.3,6.1 h. The most stable pH of NF mixing with NR was about 6.4.It is possible that the effect of NR on NF photodegradation is dependent on the pH of a solution.

关 键 词：硝苯地平 柑桔素 光降解稳定性 

分 类 号：R972.4[医药卫生—药品]