大黄虫丸抗家兔动脉粥样硬化机理研究  

Study of the Anti-atherosclerotic Mechanisms by Dahuang Zhechong Pill

作　　者：李静莉[1] 刘俊田[1] 苟伟[1] 李西宽[1] 刘传镐[1] 

机构地区：[1]西安交通大学医学院,陕西西安710061

出　　处：《中国实验方剂学杂志》2006年第5期32-34,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：陕西省自然科学基金(No.2003C115);国家自然科学基金资助项目(No.30572347)

摘　　要：目的:探讨大黄虫丸抗早期动脉粥样硬化(AS)的机制。方法:采用免疫损伤合并高脂食饵的方法复制家兔早期AS模型,检测指标包括血脂测定;血清丙二醛(MDA)测定;血管壁组织形态学观察。结果:大黄虫丸对血脂各项指标无明显影响(P>0.05),但降低血清MDA水平(P<0.05),明显缩小主动脉AS斑块面积,减少泡沫细胞层数,减轻内膜增厚。结论:大黄虫丸通过非降脂的作用机制抑制AS的形成。Aim： To observe the anti-atherosclerotic mechanisms by Dahuang Zhechong pill. Methods： The atherosclerotic model was established by hypercholesterol feeding together with immune-injured endothelium in rabbits. The levels of blood lipid and MDA in the serum were determined. Histological examination was done by light microscopes. Results： The results showed that the level of MDA was decreased and the level of blood lipid wasn＇ t significantly changed in Dahuang Zhechong pill-administered groups in comparison with the control group. Histological examination showed the reduced area of atherosclerotic plaque in aorta, the lightened intimal hyperplasia, descreased foam cells in drugadministered groups- Conclusions： Dabuang Zhechong pill can inhibit the development of early atherosclerosis by the nonlowering lipid mechanisms, including inhibition of the lipid oxidation.

关 键 词：大黄(庶虫)虫丸 动脉粥样硬化 血脂 丙二醛 

分 类 号：R285.5[医药卫生—中药学]