正交试验设计优化气相色谱分离  

Optimizing the Separation of Gas Chromatography with Orthogonal Experiment Design

作　　者：吴诗剑[1] 朱江[1] 王晨[2] 王一峰[3] 刘芳[3] 陆贻通[1] 

机构地区：[1]上海交通大学环境科学与工程学院,上海200240 [2]上海师范大学环境学院,上海200233 [3]上海市环境监测中心,上海200030

出　　处：《科技通报》2006年第3期358-361,366,共5页Bulletin of Science and Technology

基　　金：国家自然科学基金资助项目(20337010);国家基础研究重大项目(2004CB418503);上海市基础研究重点项目(04JC14051)

摘　　要：讨论了气相色谱分离甲醇、乙醇、丙酮、异丙醇混合溶液的条件。通过前期试验发现乙醇和异丙醇的分离较难,所以运用正交实验设计法,确定最佳操作参数,获取优化的分离度。采用正交实验设计法对气相色谱分离过程中所采用的温度、流量、程序升流和尾吹四个主要因素进行了试验,通过有交互作用和无交互作用作正交试验设计,确定了最佳的操作条件:炉温45℃、初始载气流量6ml/min、程序升流4ml/min、加尾吹,且尾吹的影响最显著。The condition of separating the mixed solution of methanol, ethanol, acetone and isopropyl alcohol by gas chromatograph was discussed in this paper. Because ethanol and isopropyl alcohol is difficult to separate, the orthogonal experiment design is used to define the best operation parameter and to obtain the optimization resolution. Using the orthogonal experiment design, the four major factors including temperature ,gas flow,program flow rate and aux gas were tested in the process of GC separation. Based on the orthogonal experiment design of interaction and non-interaction, the best operation condition was defined： temperature 45℃ ,initial carrier gas flow 6ml/min ,program flow rate 4ml/min and aux gas. The most significant influence is aux gas.

关 键 词：正交实验设计 气相色谱 操作条件 优化 

分 类 号：TQ014[化学工程]