非瓣膜病心房颤动与内皮功能关系的研究  

Study of the relationship between nonvalvuiar atrial fibrillation and endothelial function

作　　者：谢英[1] 李曦[1] 张维君[1] 温绍君[2] 赵瑞祥[1] 周玉杰[1] 彭新界[1] 张文[1] 张妍[1] 文杰[2] 程秀琴[1] 王龙华[1] 刘雅[2] 

机构地区：[1]首都医科大学附属北京安贞医院老年心内科,北京100029 [2]首都医科大学附属北京安贞医院高血压研究室

出　　处：《临床心血管病杂志》2006年第5期270-272,共3页Journal of Clinical Cardiology

基　　金：卫生部保健科研基金(NO:2001012)

摘　　要：目的:探讨非瓣膜病心房颤动(房颤)对内皮功能的影响。方法:选择中老年非瓣膜病房颤患者92 例(房颤组)和窦性心律者60例(对照组),采用放射免疫分析法(RIA法)测定血浆内皮素-1(ET-1)和6-酮-前列腺素F1α(6-k-PGF1α)水平,采用酶联免疫吸附双抗体夹心法(ELISA法)测定血浆血管性血友病因子(vWF)水平,观察2组间各指标的差异,并对可能影响ET-1、vWF、6-k-PGF1α水平的性别、年龄和血清肌酐、尿酸、血糖、三酰甘油、胆固醇等因素采用协方差方法分析。结果:①单因素分析,房颤组ET-1(115．11±81．84)ng／L显著高于对照组(83．81±20．60)ng／L,P<0．05,房颤组vWF(163．04±36．58)％也显著高于对照组(71．14±43．40)％, P<0．01,房颤组6-k-PGF1α(205．81±100．96)ng／L显著低于对照组(300．79±118．02)ng／L,P<0．01。②多因素分析,调整其他可能影响因素后,房颤组ET-1和vWF水平仍高于对照组(P>0．05和P<0．01),6-k- PGF1α水平仍低于对照组(P<0．05)。结论:非瓣膜病房颤患者存在内皮细胞受损和功能异常。因此应重视非瓣膜病房颤患者改善内皮功能的治疗。Objective： To investigate the influence of nonvalvular atrial fibrillation （Af） on endothelial function. Method： The plasma concentrations of endothelin-1 （ET-1） and 6-keto-prostaglandin F1α （6-k-PGF1α） were measured by radioimmunoassay （RIA） and the plasma concentration of yon Willebrand Factor （vWF） was measured by enzyme linked immunoadsorbent assay （ELISA） in 92 middle-old aged patients with nonvalvular Af （Af group） and 60 middle-old aged patients with sinus rhythm （control group） . The differences between 2 groups were determined by univariate analysis and multivariate analysis. Result： ①The plasma concentrations of ET-1 （[115.11 ± 81.84]ng/Lvs E83.8±20.60]ng/L, Pal0.05） and vWF （[163.04±36.58]% vs [71.14±43.40]%, P 〈0. 001） in Af group were significantly higher than those in the control group by univariate analysis, while the plas ma concentration of 6-k-PGF1α, in Af group was significantly lower than that in the control group （E205.81 ± 100.96] ng/L vs [300.79±118.02]ng/L, P〈0.01）.② After adjustment of the factors of sex, age and plasma levels of creatinine, uric acid, blood sugar, triglyceride and cholesterol, the plasma concentrations of ET1 （ P〉 0. 057 and vWF （ P 〈0. 017 in AF group were still higher while 6-k-PGF1α （ P 〈0. 01） in Af group lower than those in the control group respectively with analysis of covariance. Conclusion; Endothelial damage/dysfunction were found in the patients with nonvalvular Af. More attention should be paid to the improvement of endothelial function in the patients with nonvalvular Af.

关 键 词：心房颤动 内皮素1 血管性血友病因子 6-酮-前列腺素F1Α 

分 类 号：R541.7[医药卫生—心血管疾病]