血清肝细胞生长因子在新生儿急性肾功能衰竭中的变化及意义  

Changes and significance of serum hepatocyte growth factor in neonates with acute renal failur

作　　者：袁安波[1] 石晓峰[1] 上官明[1] 刘东[1] 廖琼[1] 古爱香[1] 

机构地区：[1]广东省江门市中心医院新生儿科,529070

出　　处：《中国综合临床》2006年第6期561-562,共2页Clinical Medicine of China

基　　金：广东省医学科研基金资助项目(A1999620)

摘　　要：目的探讨新生儿急性肾功能衰竭(ARF)病程中血清肝细胞生长因子(HGF)的动态变化及意义。方法采用酶联免疫吸附法,测定39例ARF新生儿(肾衰组)少尿期、多尿期和恢复期血清HGF含量,并与正常对照组36例新生儿进行比较。结果肾衰组少尿期和多尿期血清HGF水平均显著高于正常对照组[(762.6±200.4)ng/L、(503.1±167.6)ng/L比(417.5±166.3)ng/L;分别为P<0.01和P<0.05],恢复期血清HGF降至正常。肾衰组少尿期血清HGF与同期血尿素氮和血肌酐呈显著正相关(r=0.359,P<0.05;r=0.606,P<0.01)。结论在新生儿ARF病程中血清HGF呈现相应变化,该变化与肾脏的损害及修复过程密切相关。Objective To explore the significance and changes of serum hepatocyte growth factor （HGF） level in neonates with acute renal failure （ARF）. Methods The concentrations of serum HGF were determined with ELISA at the different time points in 39 neonates with ARF （ARF group） and 36 healthy controls,which were compared with those of 3b controls. Results The serum HGF levels increased significantly in ARF group at their stages of olignria and polyuria compared to the control group [ （762.6 ± 200.4） ng/L, （503.1 ± 167.6） ng/L vs （417.5 ± 166.3） ng/L,P 〈 0.01 and P 〈 0.05 ]. The serum HGF returned to normal level at the recovery stage. The serum HGF was significantly positively correlated with serum creatinine or BUN in ARF group at the stage of oliguria（ r = 0.359,P 〈 0.05 ; r = 0.606,P 〈 0.01 ）. Conclusion Serum HGF in neonates with ARF shows a dynamic change, which is closely correlated with the course of renal injury and recovery.

关 键 词：急性肾功能衰竭 肝细胞生长因子 新生儿 

分 类 号：R722.1[医药卫生—儿科]