系统性红斑狼疮患者血清IL-13、IL-12、IL-2和IFN-γ检测及意义  

SERUM LEVELS OF IL-13,IL-12,IL-2 AND IFN-γ IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

作　　者：邹吉敏[1] 袁宝军[1] 安心[1] 吴俊艳[1] 周波[1] 

机构地区：[1]华北煤炭医学院附属开滦医院检验科

出　　处：《中国煤炭工业医学杂志》2006年第6期560-561,共2页Chinese Journal of Coal Industry Medicine

摘　　要：目的探讨系统性红斑狼疮(SLE)患者血清IL-13、IL-12、IL-2和IFN-γ水平变化及意义。方法采用双抗体夹心ELISA法检测58例SLE患者(活动期16例,稳定期42例)及30例健康对照者血清IL-13、IL-12、IL-2和IFN-γ的含量。结果SLE活动组、稳定组血清IL-13、IFN-γ水平与对照组比较明显增高,差异有统计学意义(P<0.01),活动组IL-13又较稳定组增高,差异亦有统计学意义(P<0.05),IFN-γ水平略高于稳定组,但差异无统计学意义;IL-12、IL-2与对照组比较,稳定组略高,活动组略低,差异无统计学意义,但疾病活动组与稳定组比较则明显降低,差异有统计学意义(P<0.05)。SLE活动期IL-2与IL-13呈负相关(r=-0.52,P<0.05)。结论SLE患者存在细胞因子紊乱,IL-13、IL-12、IL-2及IFN-γ可能参与SLE的发病、发展,且IL-13、IL-12、IL-2水平与SLE疾病活动有关。Objective To investigate the changes of serum IL- 13, IL- 12, IL- 2, and IFN - γ levels in patients with systemic lupus erythematosus. Methods The levels of serum IL- 13, IL- 12, IL- 2, and IFN - γ were determined by ELISA, 58 patients with SLE were divided as active group（n = 16） and stable group（n = 42）. As control, 30 healthy people were also recruited. Results The levels of IL- 13 and IFN- γ in patients with SLE were significantly higher than those in controls（P〈0.01） ,serum IL-13 level in the active group was higher than that in the stable group（P〈0.05）. Compared with control, there was no significant difference in the contents of serum IL- 12 and IL- 2 in two SLE groups（P〉0. 05）, although the levels in active SLE group were slightly lower and those in the stable SLE group were slightly higher; serum IL - 12 and IL- 2 levels in the active group were significantly lower compared with those in the stable group（P〈0.05）. There was negative correlation between IL- 13 and IL- 12 in active group（r = - 0.52, P〈0.05）. Conclusion Cytokine imbalance exists in patients with SLE, serum levels of IL- 13, IL- 12, IL-2, and IFN - γ might participate in immunopathological mechanism of SLE and IL - 13, IL- 12, IL- 2 are associated with SLE activity.

关 键 词：红斑狼疮 系统性 白细胞介素 干扰素 

分 类 号：R593.241[医药卫生—内科学]