^(67)Ga心肌显像诊断心肌炎的实验研究  

^(67)Ga myocardial imaging for the detection of myocarditis in experimental model

作　　者：王齐冰[1] 浦寿月[1] 杨英珍[1] 陈绍亮[2] 陈可靖[2] 杨俊华[3] 金佩英[1] 武佩佩[1] 陈灏珠[1] 

机构地区：[1]上海医科大学中山医院,上海市心血管病研究所200032 [2]上海医科大学中山医院核医学科 [3]上海医科大学病理教研室

出　　处：《中华核医学杂志》1996年第3期182-184,共3页Chinese Journal of Nuclear Medicine

基　　金：卫生部科研基金资助

摘　　要：以柯萨奇 B_3病毒感染 BALB/c 小鼠,制备心肌炎模型,用^(67)Ga 心肌显像检测炎症心肌。结果显示,正常组20只小鼠心肌摄^(67)Ga 率很低,给药后24～72小时心肌显像均呈阴性。心肌炎组30只,给药后24、48及72小时炎症心肌的放射性浓聚均明显高于正常对照组,给药后48小时最高,且高出其他组织1.65～20.55倍,其放射性浓聚程度与心肌炎程度呈正相关;24小时心肌显像阴性,48小时及72小时心肌显像均呈阳性,3只心肌炎程度较重者96小时显像也呈阳性。故注射^(67)Ga 后48及72小时心肌显像能无创性地检测心肌炎症。PURPOSE To assess the feasibility of ^(67)Ga myocardial imaging in detecting myocarditis.METHODS An exper- imental myocarditis model induced by Coxackic B3 virus in BALB/c mice was compared with normal controls in ^(67)Ga myocardial scintigraphy.RESULTS In normal mice group (n=20),tissue distribution studies documented low myocardial uptake of ^(67)Ga at 24～72 hours after administration.All had negative myocardial imagings.Contrarily,significant myocardial uptake of ^(67)Ga was found in the myocarditis mice group (n=30),in which the peak accumulation of ^(67)Ga in inflammatory myocardium was at 48 hours after injection,much higher than that of control group,and was 1.65～20.55 times higher than that of other tissues.The ^(67)Ga uptake was highly correlated with the extent of the myocardial lesions.Positive imagings were visualized at 48～72 hours af- ter ^(67)Ga administration,but myocardial imagings were negative at 24 and 96 hours,except 3 with severe pathologic lesions which bad positive imagings at 96 hour.CONCLUSIONS The study demonstrated that cardiac imaging with ^(67)Ga may be useful in the diagnosis of myocarditis in clinical.

关 键 词：心肌炎 放射性核素显像 镓 诊断 

分 类 号：R542.210.4[医药卫生—心血管疾病]