慢性肺原性心脏病呼吸衰竭患者红细胞内外离子含量研究  

The Content of Magnesium Inorganic Phosphorous in Intracellular and Extracellular Fluid of Patients with Respiratory Failure in Chronic Cor Pulmonale

作　　者：田莉莉[1] 吴凝萃[1] 

机构地区：[1]沈阳呼吸疾病研究所

出　　处：《中国医科大学学报》1996年第3期285-287,共3页Journal of China Medical University

摘　　要：用原子吸光仪及超微量比色法，紫外分光光度仪分别对３９例肺心病呼衰患者血清镁（ＳＭｇ）、红细胞镁（ＲＭｇ）、尿镁（ＵＭｇ），血清磷（ＳＰ）、红细胞磷（Ｒｐ）、尿磷（Ｕｐ）及红细胞２，３－二磷酸甘油酸（Ｒ２，３－ＤＰＧ）进行检测。结果表明：ＳＭｇ、ＲＭｇ明显降低（Ｐ＜０．０１；Ｐ＜０．０５）。ＵＭｇ相对增多，提示肺心病呼衰患者存在低镁血症及机体缺镁。ＳＰ降低占４２％，ＲＰ降低（Ｐ＜０．０５），ＵＰ排出相对增多，说明肺心病呼衰患者存在低磷血症及机体缺磷。尽管病人明显缺氧，但Ｒ２，３－ＤＰＧ却无升高（Ｐ＞０．０５），二氧化碳潴留重组Ｒ２，３－ＤＰＧ降低（Ｐ＜０．０５），ＲＰ与Ｒ２，３－ＤＰＧ呈正相关（ｒ＝０．７０２，Ｐ＜０．００１），说明肺心病呼衰患者ＰａＣＯ２、ＲＰ是影响Ｒ２，３－ＤＰＧ含量的重要因素。ed Cell Mg(RMg),Serum Mg(SM),Urine Mg(UMg),Red Cell P(RP), Serum P(SP),Urine P(UP)and R 2,3-DPG Values of 39 respiratory failure patients in chronic cor pulmonale weremeasured by atomic absorption spectrophotometer ,ultramicro-Colorimetric method,and ultravioletspectrophotometer respectively.The results showed that SMg,RMg,SP,and RP were decreased。This indicated that Mg and P deficiency existed in chronic cor pulmonale patients with respiratory fail-ure.The study also showed that R 2,3-DPG level was normal in 35 chronic cor pulmonale patientswith marked hypoxaemia. But R 2,3-DPG was reduced in 24 Chronic cor pulmonale patients withmarked hypercapnia. A significant positive correlation was found between RP and R 2,3-DPG(r=0.702,P<0.001) in chronic cor pulmonale patients with hypercapnia. This indicated that hypercapniaand RP were irnportant factors to influence R 2,3-DPG levels.

关 键 词：肺心病 呼吸衰竭 红细胞 二磷酸甘油酸 

分 类 号：R541.506[医药卫生—心血管疾病] R563.802[医药卫生—内科学]