除草剂噻磺隆的合成  

Synthesis of Herbicide Thifensulfuron

作　　者：陆阳[1,2] 冯世龙[2] 董超宇[3] 陶京朝[1] 张志荣[4] 徐固华[2] 

机构地区：[1]郑州大学化学系,郑州450001 [2]信阳农专有机化学教研室,河南信阳464000 [3]开封大学化工系,河南开封475000 [4]安徽省华祥农药化工公司,合肥230041

出　　处：《化工文摘》2006年第3期40-41,共2页

摘　　要：报道了以氯甲酸甲酯和2-羧甲基-3-磺酰氨基噻吩为起始原料合成除草剂噻磺隆的方法。原料2-羧甲基-3-磺酰氨基噻吩与氯甲酸甲酯生成2-甲氧羰基-3-磺酰胺基甲酸甲酯噻吩,再与2-氨基-4-甲氧基-6-甲基均三嗪反应生成噻磺隆。避免了异氰酸酯路线的种种缺点,具有收率高、含量高、成本低的特点。以2-羧甲基-3-磺酰氨基噻吩计,总收率为77.73%,原药纯度达到93.6%。a method for preparation of thifensulfuron from methyl chloroformate and 2-methoxycarbonyl- 3- aminosulfonylthiophe as starting material was reported 2-methoxycarbonyl-3-am inosulfonylthiophene reacts with methyl chloroformate to give 2- methoxycarbonyl-3-am inosulfonylthiophene,thifensulfuron will be obtained after reaction of the above product 2-amino-4-methoxy-6-methyl-1,3,5-triazine.this is an economical method to prepare thifensulfuron in high yield and good purity, avoiding the shortcoming of the isocyanate route .the total yield reaches77.73% based on 2-methoxycarbonyl-3-am inosulfonylthiophene and the purity is 93.6%.

关 键 词：噻磺隆 氯甲酸甲酯 磺酰脲 除草剂 

分 类 号：TQ174.759[化学工程—陶瓷工业] TQ457.29[化学工程—硅酸盐工业]