114例HBsAg阳性孕妇及其新生儿PBMC感染HBV的状况  

The status of HBV infection in peripheral blood mononuclear cells from 114 HBsAg-positive mothers and their newborns

作　　者：王效军[1] 王素萍[2] 李铁钢[3] 冯永亮[2] 

机构地区：[1]广东医学院预防医学教研室,广东湛江524023 [2]山西医科大学流行病学教研室,山西太原030001 [3]广州市疾病预防控制中心,广东广州510080

出　　处：《广东医学院学报》2006年第2期131-133,共3页Journal of Guangdong Medical College

基　　金：国家自然科学基金资助(30070669)

摘　　要：目的:了解HB sA g阳性孕妇及其新生儿PBM C HBV感染状况。方法:采用原位杂交(ISH)技术检测114例孕妇和新生儿PBM C涂片中HBV DNA。结果:114例HB sA g阳性孕妇及其新生儿PBM C HBV DNA的检出率分别为28.07%(32/114)和32.46%(37/114);HB sA g阳性孕妇与其新生儿之间的PBM C HBV感染存在一致性(K app a=0.52,P<0.01)。结论:证实HB sA g阳性孕妇与其新生儿之间的PBM C HBV感染存在一致性。Objective：To observe the status of HBV infection in peripheral blood mononuclear cells （PBMC） from the HBsAg-positive mothers and their neonates. Methods;In situ hybridization （ISH） was used to detect HBV DNA in PBMC smear from 114 HBsAg-positive mothers and theirs newborns. Results：The positive rates of the PBMC HBV infection of the mothers and their neonates were 28. 07% and 32.46%, respectively. There was an agreement of the HBV infection status between the mothers and their newborns （Kappa=0. 52, P〈 0.01）. Conclusion：The result suggests that the HBV infection status from the mothers agrees with that from their newborns.

关 键 词：外周血单个核细胞 乙型肝炎病毒 原位杂交 

分 类 号：R512.62[医药卫生—内科学]