氟脲嘧啶脱氧核苷化疗泵持续给药输液配伍的稳定性研究  

HPLC study on the stability of floxuridine in continuous infusion solutions

作　　者：方罗[1] 国强[2] 林能明[1] 张彩霞[1] 

机构地区：[1]浙江省肿瘤医院,杭州310022 [2]浙江大学医学院附属妇产科医院,杭州310006

出　　处：《药物分析杂志》2006年第4期469-472,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:考察氟脲嘧啶脱氧核苷与7种不同输液配伍的稳定性。方法:将氟脲嘧啶脱氧核苷按临床常规剂量加入输液中,放置在不同温度(25,35℃)下,用高效液相色谱法测定配伍后不同时间点输液中氟脲嘧啶脱氧核苷的含量,同时观察外观性状、pH、紫外吸收光谱和 HPLC 色谱图的变化。结果:不同温度条件下,氟脲嘧啶脱氧核苷与7种常用输液的配伍溶液在120 h内性状、pH(RSD<2%)和氟脲嘧啶脱氧核苷的含量(RSD<2%)、紫外吸收光谱和 HPLC 色谱图无明显变化。结论:氟脲嘧啶脱氧核苷与7种常用输液配伍至少在观察的120 h 内稳定。Objective ：To observe the stability of floxuridine injection in infusion solution. Methods：To determinate the content of floxuridine in 7 kinds of infusions using RP - HPLC, the color and clarity were assessed, and pH was measured at 25 % and 35 % for 120 h, in the meantime, to inspect the change of ultraviolet absorption spectrum utilizing diode array detector and observe the change of chromatogram. Results：All solution were no or few changes in the appearance,pH,content,ultraviolet absorption spectrum and chromatogram at 25℃ and 35℃ for 120 h. Conclusion：The floxuridine injection in infusion solutions kept relatively stability in 120 h.

关 键 词：氟脲嘧啶脱氧核苷(FUDR) 输液 稳定性HPLC 

分 类 号：R917[医药卫生—药物分析学]