逆行胃电刺激对健康人水负荷、摄食量和胃排空的影响  

Effect of retrograde gastric electrical stimulation on water load,food intake and gastric emptying in healthy humans

作　　者：姚树坤[1] 柯美云[1] 王智凤[1] 许大波[1] 张艳丽[1] 陈建德[2] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院消化科,北京100370 [2]德克萨斯大学医学分校胃肠科

出　　处：《基础医学与临床》2006年第5期513-517,共5页Basic and Clinical Medicine

摘　　要：目的观察逆行胃电刺激(RGES)对健康人胃容受性、摄食量和胃排空的影响。方法选择健康志愿者12人。沿胃大弯距幽门5 cm处放置一对黏膜电极,以胃动过速的频率9 cyc les/m in,波宽500 m s,强度5 mA的脉冲信号进行RGES。进行水负荷试验、摄食试验和核素闪烁扫描固体胃排空试验来评价RGES的效果。结果与对照阶段相比,RGES可引起摄水量减少13%(P<0.01),摄食减少16%(P<0.001),胃半排空时间延迟33%(P<0.05),120 m in食物存留率增加15%(P<0.05)。水负荷试验、摄食试验和胃排空试验应用的RGES参数没有引起显著症状。结论急性RGES可以显著减少摄水摄食,延缓胃排空,且不引起明显症状。Objective To investigate the effects of retrograde gastric electrical stimulation （RGES） on gastric accommodation, food intake, and gastric emptying in humans. Methods RGES with a tachygastrial frequency of 9 cycles per minute was performed via a pair of submucosal gastric electrodes implanted 5 cm above the pylorus along great curvature in 12 healthy volunteers. The water load test, food intake test and scintigraphic gastric emptying of test were performed to assess the efficacy of RGES. Results RGES resulted in a reduction in consumption of water by 13% （P 〈0. 001 ）, a reduction in food intake by 16% （P 〈0. 01 ）, an increase in half time of gastric emptying （P 〈 0. 05 ）by 33% and an increase of retention（ P 〈 0. 05 ） of a solid meal by 15%. No significant symptom was recorded during RGES with the parameters used for the water load, food intake and scintigraphic gastric emptying tests. Conclusions Acute RGES at a tachygastrial frequency results in a significant reduction of gastric accommodation and food intake, and a delay in gastric emptying without inducing any unacceptable symptoms. It may be applied as a potential therapy for obesity.

关 键 词：胃电刺激 胃排空 

分 类 号：R589.2[医药卫生—内分泌]