脉冲染料激光治疗充血性瘢痕的机理研究  

A basic study and clinical trial of 585 nm pulsed dye laser in the treatment of congestive scars

作　　者：郭丹凤[1] 王德昌[2] 周兴亮[1] 宫昔愿[1] 韩继芹[1] 

机构地区：[1]山东大学临床医学院济南市中心医院整形外科,250013 [2]山东大学临床医学院省立医院

出　　处：《中华整形外科杂志》2006年第3期213-215,共3页Chinese Journal of Plastic Surgery

摘　　要：目的 研究585 nm的闪光灯泵浦脉冲染料激光（FLPDL）对充血性瘢痕的影响.方法 对治疗前、治疗后的瘢痕行常规病理、胶原纤维VG染色及兔抗人八因子多抗行微血管染色以观察FLPDL对胶原及瘢痕内微循环的影响.同时行临床观察及记录.结果 PDL治疗后瘢痕内毛细血管减少,瘢痕内胶原沉积下降,临床症状明显改善.结论 ①585 nm FLPDL激光通过破坏瘢痕内微血管,使胶原降解增多,合成减少.从而有效改善充血性瘢痕的症状、高度、皮肤纹理、颜色等.②其对瘢痕形成的病理过程进行了有效干预,因此,也可以用于预防伤后瘢痕增生.③临床治疗需3次左右,每次间隔应为4～6周.Objective To study the biological effects of 585 nm pulsed dye laser （FLPDL） in the treatment of congestive scar. Methods By histological study, collagen VG staining and microvascular staining, we investigated the changes of collagen fibers and the density of microvessels in the congestive scars after FLPDL treatment. Results Histological and immunohistochemistry examinations showed that FLPDL achieved normal vascularity in the scar after over 3 times of treatment. Conclusions PDL treatment can change fundamentally the physiology of wound healing if applied in the early phases.

关 键 词：585nm脉冲染料激光 充血性瘢痕 微血管 胶原纤维 

分 类 号：R622[医药卫生—整形外科]